PD403 - RENOPROTECTIVE ROLE OF VITAMIN D IN PATIENTS WITH DIABETIC NEPHROPATHY POST SLEEVE GASTRECTOMY

PD403

RENOPROTECTIVE ROLE OF VITAMIN D IN PATIENTS WITH DIABETIC NEPHROPATHY POST SLEEVE GASTRECTOMY

A. Aladel^1,*, L. Alagel¹, F. R. Alquthami¹, M. M. A. Abulmeaty¹

¹Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia

Rationale: Bariatric surgery (BS) effectively manages obesity and often leads to remission of type 2 diabetes (T2DM) and improvements in related comorbidities. However, the potential renoprotective role of vitamin D supplementation in diabetic nephropathy (DN) following bariatric surgery remains unclear. This study assessed the relationship between duration of vitamin D supplementation and postoperative outcomes after sleeve gastrectomy (SG), and evaluated whether preoperative serum 25(OH)D levels can predict DN in participants undergoing BS.

Methods: A retrospective cohort study included 107 participants with obesity, T2DM, and DN (UACR ≥30 mg/g) undergoing SG at King Saud Medical City between August 2023 and May 2024. Clinical, anthropometric, and biochemical parameters were assessed preoperatively and 3 months postoperatively. Vitamin D supplementation was provided for at least 2 weeks before surgery. Participants were stratified by serum 25(OH)D status (<50 nmol/L = deficient; ≥50 nmol/L = sufficient). Statistical analyses included independent t-tests, chi-square tests, paired t-tests, Spearman correlation, and multivariable linear regression.

Results: At baseline, among the 107 participants, 68% had vitamin D deficiencies. Significant declines in BMI, HbA1c, and UACR were noted after SG (p<0.001). Serum 25(OH)D was a significant negative predictor of postoperative UACR (β = −1.04, p = 0.006). Furthermore, lower UACR and increased postoperative 25(OH)D were related to longer preoperative supplementation (9–12 weeks) (p<0.05). Participants with adequate levels of 25(OH)D at baseline showed a negative correlation with postoperative adiposity indices (weight, BMI, and EBW).

Conclusion: Baseline serum vitamin D levels may serve as a predictive marker for renal outcomes after SG in participants with DN. Longer preoperative vitamin D supplementation may contribute to improved kidney outcomes in this population.

Disclosure of Interest: None declared