P462 - MODIFIED CROHN’S DISEASE EXCLUSION DIET IN MULTI-ETHNIC ASIAN SETTING: A PILOT OBSERVATIONAL STUDY

P462

MODIFIED CROHN’S DISEASE EXCLUSION DIET IN MULTI-ETHNIC ASIAN SETTING: A PILOT OBSERVATIONAL STUDY

C. K. Tan^1,2, A. Wong³, Y. Huang³, K. L. Ling¹, T. L. Ang^1,2, S. H. Koo⁴, J. Ong^1,2,*

¹Department of Gastroenterology and Hepatology, Changi General Hospital, ²Medicine Academic Clinical Programme, Singhealth Duke-NUS Academic Medical Centre, ³Department of Dietetics, ⁴Research Lab, Changi General Hospital, Singapore, Singapore

Rationale: Crohn’s disease exclusion diet (CDED), a nutritional intervention based on Mediterranean diet, is well-tolerated and effective therapy for Crohn’s disease (CD) in Western populations. This study aims to evaluate the feasibility and tolerability of using CDED as a nutritional intervention in Asian adults with CD.

Methods: This is a pilot prospective observational study using 24-weeks CDED in adults with CD. The original CDED was adapted to foods commonly eaten in Asia. Patients with active CD were offered CDED as monotherapy or as an adjunct treatment to drug therapy. Participants were seen at baseline, week 6 and week 12 to monitor dietary compliance and disease activity. Compliance was monitored by physician and dietitian (24-hour dietary recall and 3 day food diary). The primary endpoint was tolerance to CDED at week 12; secondary endpoints were compliance to CDED and biomarker normalization.

Results: 8 participants were recruited from November 2022 to September 2024. Three participants received CDED as monotherapy, the rest received biologics in combination with CDED. All participants were able to tolerate 24 weeks of CDED and were mostly compliant to CDED. At week 12, 50% of participants had a reduction of C-reactive protein (CRP) and faecal calprotectin (FC). At week 24, 33% achieved normalisation of CRP and 50% normalisation of FC. Two participants who received CDED as monotherapy had biomarker normalization at week 12. There were two participants who developed worsening of CD during the study period, including one who was on CDED monotherapy; necessitating change of therapy.

Conclusion: This is the first study using modified CDED as a nutritional intervention in Asian adults with CD. Future study should examine the efficacy of CDED in maintenance of disease remission.

Disclosure of Interest: None declared