P191 - THE GLOBAL LEADERSHIP INITIATIVE ON MALNUTRITION CRITERIA FOR THE DIAGNOSIS OF MALNUTRITION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

P191

THE GLOBAL LEADERSHIP INITIATIVE ON MALNUTRITION CRITERIA FOR THE DIAGNOSIS OF MALNUTRITION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

N. Papageorgiou¹, M. Chourdakis¹, A. Papaemmanouil¹, E. Pagkalidou², O. Giouleme¹, A. Triantafyllou¹, A. B. Haidich¹, X. Theodoridis^1,*

¹School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, ²Department of Medicine, University of Ioannina, Ioannina, Greece

Rationale: Malnutrition is highly prevalent among patients with inflammatory bowel disease (IBD) worldwide and is associated with adverse clinical outcomes. Given that the Global Leadership Initiative on Malnutrition (GLIM) criteria represent a novel framework for diagnosing malnutrition in patients with IBD, this study aims to assess their diagnostic accuracy in identifying malnutrition in comparison to the Subjective Global Assessment (SGA).

Methods: A systematic literature search was conducted across PubMed, Scopus, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Epistemonikos, to identify eligible studies. Moreover, clinical trial registries, grey literature, and the reference lists of the included studies were systematically reviewed. Study selection, data extraction, and quality assessment were performed independently by two reviewers to ensure methodological rigor. A bivariate mixed-effects model was employed to derive pooled estimates of sensitivity and specificity, using the SGA as the reference test.

Results: Three primary studies were included in this systematic review. The GLIM criteria exhibited high sensitivity (0.80, 95% CI: 0.68–0.88) and moderate specificity (0.71, 95% CI: 0.53–0.84) when compared to the SGA. The certainty of the evidence supporting these findings was rated as very low.

Conclusion: The GLIM criteria show promise as an effective tool for diagnosing malnutrition in patients with IBD. However, these findings should be interpreted with caution. Further validation is necessary, requiring additional diagnostic accuracy studies to enhance their reliability and establish their clinical applicability.

Disclosure of Interest: None declared