PD033 - NON-INVASIVE ASSESSMENT OF SARCOPENIA-RELATED PARAMETERS IN PATIENTS WITH LIVER CIRRHOSIS

PD033

NON-INVASIVE ASSESSMENT OF SARCOPENIA-RELATED PARAMETERS IN PATIENTS WITH LIVER CIRRHOSIS

J. Martinov Nestorov^1,2,*, M. Bezmarevic³, M. Stojkovic Lalosevic^1,2, S. Stojkovic¹, N. Pejic¹, T. Glisic^1,2, D. Popovic⁴, S. Zgradic⁵, V. Milivojevic^2,5, I. Rankovic¹

¹Hepatology, Clinic for gastroenterohepatology, University Clinical Center of Serbia , ²School of Medicine, University of Belgrade, ³Department of Hepatobiliary and Pancreatic Surgery, Clinic for General Surgery, Military Medi-cal Academy, University of Defense, ⁴ Department of Gastroenterology, Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", ⁵Gastroenterology, Clinic for gastroenterohepatology, University Clinical Center of Serbia , Belgrade, Serbia

Rationale: Liver cirrhosis is often accompanied by sarcopenia, which is associated with a poorer prognosis. Due to the limited availability of radiological methods for assessing muscle mass, interest is increasing in the use of simple noninvasive assessment methods, such as anthropometric parameters and questionnaires, in everyday clinical practice.The aim of our study was to examine the association between muscle strength, anthropometric parameters, and SARC-F score with clinical indicators of cirrhosis severity, including the MELD and Child-Pugh scores.

Methods: This retrospective study included 50 adult patients with diagnosed liver cirrhosis. Muscle strength was assessed using the handgrip strength test. Anthropometric assessment included measurement of MAC, TST and calculation of MAMC. The risk of sarcopenia was assessed using the SARC F questionnaire, while nutritional risk was assessed using the NRS-2002 score. Disease severity was evaluated using the MELD and Child-Pugh scores. Statistical analysis was performed using SPSS software

Results: The study included 50 patients with a mean age of 53±13 years. Reduced muscle strength was detected in 56% of patients, while 30% had a SARC-F score ≥ 4. A statistically significant positive association was found between the SARC-F score and both the MELD and Child-Pugh scores. The SARC-F was also associated with lower albumin and higher INR. Handgrip strength showed a negative correlation with MELD score, but without statistical significance. Anthropometric parameters showed no significant association with disease severity.

Conclusion: The results indicate that functional screening using the SARC-F questionnaire shows a significant association with disease severity in patients with liver cirrhosis. Simple functional methods may be useful for early identification of patients at increased risk in everyday clinical practice.

Disclosure of Interest: None declared