PT03 - DYNAPENIA AND MORTALITY IN USERS OF HEMODIALYSIS SERVICES: A BRAZILIAN COHORT STUDY

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PT03

DYNAPENIA AND MORTALITY IN USERS OF HEMODIALYSIS SERVICES: A BRAZILIAN COHORT STUDY

 

L. P. Klippel1,*, C. A. Martins2, K. S. Barbosa3, L. B. Leandro3, M. Cattafesta2, A. C. Cunha4, A. C. O. Soares2, C. B. Prado2, J. R. Ferreira2, F. Z. Peterle1, J. A. Souza5, F. K. Haraguchi1, E. H. Furtado 6, E. S. Neto2, L. B. Salaroli1

1Graduate Program in Nutrition and Health, 2Graduate Program in Collective Health, 3Integrated Health Education, 4Occupational therapy, Federal University of Espirito Santo, Vitória, Brazil, 5 Centro de Investigação de Montanha , Instituto Politécnico de Bragança, Bragança, Portugal, 6Physiological Sciences, Federal University of Maranhão , São Luís, Brazil

 

Rationale: Dynapenia has been associated with a higher risk of hospitalizations, mortality and worse prognosis in individuals undergoing hemodialysis. In this sense, the measurement of muscle strength is recommended.

Methods: This study included 363 individuals undergoing hemodialysis. Clinical variables were extracted from a database from a study conducted in 2019 and followed until 2022. Mortality data were obtained through death certificates registered in the Mortality Information System. Dynapenia was defined by cutoff points <16 kg for women and <27 kg for men. The model was analyzed by Cox regression, and survival were analyzed by the Kaplan-Meier Curves with log-rank test. Analyses were performed in R (4.4.1), with a significance level of p<5%.

Results: The sample included 363(37.7%) individuals who died during the follow-up. According to the survival curves, individuals with dynapenia have higher mortality, comparing the number of observed and expected deaths. Independently, it was seen that dynapenia increases the risk of death by 1.67 (95%CI 1.32 – 2.11, p <0.001). 

Conclusion: The results suggest that dynapenia can be considered a predictor of mortality. Therefore, the measurement of muscle strength may be used in nutritional screening and assessment of individuals with chronic kidney disease undergoing hemodialysis.

Disclosure of Interest: None declared