PP236 - LOWER TRIGLYCERIDE–CHOLESTEROL–BODY WEIGHT INDEX INDEPENDENTLY PREDICTS IN‑HOSPITAL COMPLICATIONS

PP236

LOWER TRIGLYCERIDE–CHOLESTEROL–BODY WEIGHT INDEX INDEPENDENTLY PREDICTS IN‑HOSPITAL COMPLICATIONS

Y. Li^1,2,*, M. Zhu¹

¹Department of General Surgery, Department of Hepato-bilio-pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, ²Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

Rationale: We investigated whether the triglyceride–cholesterol–body weight index (TCBI), an integrated nutritional–metabolic marker, predicts in‑hospital complication risk.

Methods: In this multicentre observational study, 8,288 hospitalized adults with complete anthropometric and laboratory data were analysed. TCBI was log‑transformed (TCBI‑LN) and evaluated against in‑hospital complications using univariate tests and multivariable logistic regression, with restricted cubic splines (RCS) and subgroup analyses exploring dose–response and consistency across strata.

Results: Overall, 403 patients (4.9%) developed complications, and TCBI‑LN was lower in patients with complications than in those without (6.83 ± 0.71 vs 7.10 ± 0.83; P < 0.001). In multivariable models, higher TCBI‑LN remained independently associated with lower complication risk, as shown for continuous TCBI‑LN across four logistic models in the accompanying table. All six logistic models added demographics, comorbidities, nutritional and clinical factors stepwise, and the inverse association between TCBI‑LN and complications remained stable. RCS analysis demonstrated an approximately linear inverse association between TCBI‑LN and complication risk, as illustrated by the spline figure. The protective association was broadly consistent across major subgroups, and a Youden‑based cutoff identified low‑, intermediate‑ and high‑risk groups with complication rates of 2.9%, 5.1% and 6.3%.

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Conclusion: Lower TCBI‑LN was independently associated with higher in‑hospital complication risk in this large real‑world cohort, suggesting that TCBI may be a practical routine marker for early risk stratification.

Disclosure of Interest: None declared