P980 - TRENDS IN PALLIATIVE HOME PARENTERAL NUTRITION IN THE CZECH REPUBLIC: RETROSPECTIVE ANALYSIS FROM THE NATIONAL HOME PARENTERAL NUTRITION REGISTRY

P980

TRENDS IN PALLIATIVE HOME PARENTERAL NUTRITION IN THE CZECH REPUBLIC: RETROSPECTIVE ANALYSIS FROM THE NATIONAL HOME PARENTERAL NUTRITION REGISTRY

R. Szotkowská^1,*, A. Ouřadová¹, K. Koudelková¹, P. Těšínský¹, M. Šenkyřík², P. Wohl³, J. Gojda¹ on behalf of Czech HPN Working Group

¹Department of Internal Medicine, University Hospital Královské Vinohrady and Third Faculty of Medicine, Charles University, Prague, ²Department of Internal Medicine and Gastroenterology, University Hospital Brno and Faculty of Medicine, Masaryk University Brno, Brno, ³Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Rationale: With the advent of modern oncology treatment and increasing life expectancy of patients with malignancies the prevalence of palliative HPN has increased worldwide. To assess this trend in the Czech Republic, we performed analysis of data from the Czech National Home Parenteral Nutrition Registry (REDNUP).

Methods: The Czech National HPN registry REDNUP has been prospectively collecting data on individual patients indicated for HPN across the country. Basic demographic characteristics, prevalence, incidence, indications and HPN complications were analyzed. Descriptive analysis and time–to–event using exploratory data analysis.

Results: Since 2005, 575 patients have been indicated for palliative HPN, representing approximately 25% of all patients enrolled in REDNUP. In 2018-2024, the average incidence was 62.4 (±13.4) patients per year. The average age was 61 (±13.7) years. The most common indication for palliative HPN was cancer and its treatment (92%), and the most commonly reported syndromes were obstruction (55%), short bowel syndrome (7.7%), malabsorption (7%), and anorexia (5.6%). Overall, the majority of patients had a low performance status at HPN initiation (PS WHO3: 42.8%; PS WHO 2: 31.3%). The mean duration of HPN in the entire cohort was 0.5 years (181.9 catheter days per patient), with a median of 0.2 years. The incidence of catheter sepsis for was 1.05 (±1.42) per 1000 catheter days.

Conclusion: Patients on palliative HPN represent an increasing proportion of patients indicated for HPN in Czech Republic. Based on the data, we can conclude that the threshold to initiate palliative HPN was rather low. Despite a lower performance status and a median duration of nutrition administration less than 3 months, there was no evidence of a higher complication rate compared to non-palliative indications.

Disclosure of Interest: None declared