PD418 - FROM PRISM TO COPD: ASSOCIATIONS BETWEEN DIETARY DAGES, MUSCLE OXYGENATION, AND MULTIDIMENSIONAL FUNCTIONAL PARAMETERS

PD418

FROM PRISM TO COPD: ASSOCIATIONS BETWEEN DIETARY DAGES, MUSCLE OXYGENATION, AND MULTIDIMENSIONAL FUNCTIONAL PARAMETERS

B. Demirer^1,*, M. Güneş²

¹Nutrition and Dietetics, ²Physiotherapy and Rehabilitation, Karabuk University, Karabük, Türkiye

Rationale: Systemic inflammation and muscle dysfunction are pivotal in obstructive lung diseases. Dietary advanced glycation end-products (dAGEs) may drive these impairments through oxidative stress. This study investigates the associations between dAGE-to-energy ratio, muscle functionality, and symptom burden across the PRISM (Preserved Ratio Impaired Spirometry) and COPD (Chronic Obstructive Pulmonary Disease) spectrum.

Methods: Patients with COPD (n=25) and PRISM (n=22) were included in this cross-sectional study. Dietary intake was assessed via 3-day food records to calculate dAGE-to-energy ratios. Evaluations included pulmonary function, muscle strength (MIP, MEP, Quadriceps), inspiratory muscle endurance (IME), exercise capacity (6-minute walk test (6MWT)), muscle oxygenation (resting SmO2), and symptoms (COPD Assessment Test (CAT)).

Results: COPD patients had significantly higher dAGE-to-energy ratios (6.57±1.45 vs 4.01±1.04; p<0.001) and symptom burden (CAT: 17.64 ±5.92 vs 14.36 ± 4.46; p=0.040) than PRISM patients. Significant impairments were observed in COPD for 6MWT, IME, and Quadriceps strength (p < 0.05). In age-adjusted analyses for PRISM, higher dAGE-to-energy ratio was significantly associated with decreased muscle oxygenation (SmO₂) (r=-0.380, p<0.05). In COPD, however, dAGE intake was not significantly associated with functional parameters; instead, 6MWT was primarily linked to MIP (r = 0.629, p < 0.001).

Conclusion: The absence of dAGE-functionality associations in COPD, contrasted with significant correlations in PRISM, suggests dietary glycation drives early metabolic muscle dysfunction, whereas mechanical factors dominate advanced disease. These findings underscore the clinical importance of the PRISM stage as a strategic phase for low-dAGE nutritional interventions to preserve muscle functionality before irreversible airway obstruction develops.

Disclosure of Interest: None declared