O024 - USEFULNESS OF A NOVEL MULTI-FREQUENCY BIOELECTRICAL IMPEDANCE ANALYSIS FOR ASSESSING MUSCLE VOLUME FOR GLIM ASSESSMENT IN CRITICALLY ILL PATIENTS

O024

USEFULNESS OF A NOVEL MULTI-FREQUENCY BIOELECTRICAL IMPEDANCE ANALYSIS FOR ASSESSING MUSCLE VOLUME FOR GLIM ASSESSMENT IN CRITICALLY ILL PATIENTS

T. Miyagi^1,*, N. Kanda², M. Yoshida³, S. Suganuma⁴, A. Kariya⁵, K. Nakamura⁴

¹Department of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Yokohama City University, Kanagawa, ²Division of General Internal Medicine, Jichi Medical University, Tochigi, ³Department of Health Data Science, Graduate School of Data Science, Yokohama City University, ⁴Critical Care Medicine, Yokohama City University Hospital, ⁵Nursing Department, Yokosuka General Medical Center, Kanagawa, Japan

Rationale: Optimal muscle volume assessment in critically ill patients is undetermined. Although bioelectrical impedance analysis (BIA) offers an advantage in assessing whole-body muscle volume, studies in this population are limited due to its limitation for edematous condition. In this study, we evaluated the utility of a novel BIA device capable of calculating resistance at 140 different frequencies.

Methods: This single-center, prospective study at Yokohama City University Hospital included adult patients admitted to the intensive care unit (ICU), expected to require ≥2 days of mechanical ventilation and ambulatory before admission (Sep 2024–Feb 2025). Muscle volume by BIA was calculated using intracellular fluid volume, age and sex. Total skeletal muscle volume, determined by tracing muscle area on abdominal CT, was used as the reference. Femoral muscle area and calf circumference were measured by ultrasound (US) and anthropometry, respectively. Energy expenditure (EE) was measured by indirect calorimetry. We evaluated the correlation between the reference and muscle volume by other methods. We then assessed their performance in identifying sarcopenia, determined by Iritani's criteria using CT-measured muscle volume and in GLIM assessment. We also investigated the association between EE and muscle volume.

Results: A total of 40 patients (18 surgical and 22 medical) were analyzed. BIA showed the highest correlation coefficient of 0.78, followed by US and anthropometry. BIA identified sarcopenia, with an area under the receiver operating characteristic curve of 0.82 (at optimal cut-off, sensitivity 79.3% and specificity 90%), and GLIM using BIA could identify severe malnutrition patients. BIA showed the strongest correlation with EE, followed by CT, US, and anthropometry.

Conclusion: In ICU patients, BIA can be useful for assessing muscle volume.

Disclosure of Interest: T. Miyagi Grant / Research Support from: This study was supported by a research grant from Terumo Corporation., N. Kanda: None declared, M. Yoshida: None declared, S. Suganuma: None declared, A. Kariya: None declared, K. Nakamura: None declared