PD034 - ACROMEGALY AND MORPHOFUNCTIONAL ASSESSMENT

PD034

ACROMEGALY AND MORPHOFUNCTIONAL ASSESSMENT

A. Puig Perez^1,*, M. F. Mucarzel Suarez-Arana¹, A. Rodriguez², A. Zabalegui Eguinoa¹, R. Cartiel Vesperina¹, B. L. Biagetti³, R. Burgos Pelaez¹, F. X. Palmas Candia¹

¹Unidad de Soporte Nutricional, ²Departamento de Diagnóstico por la Imagen, ³Endocrinología, Hospital Universitario Vall de Hebron, Barcelona, Spain

Rationale: Growth hormone (GH) and insulin growth factor-1 (IGF-1) play key roles in regulating body composition (BC). However, evidence on advanced morphofunctional phenotyping in acromegaly remains scarce. This study aimed to compare morphofunctional characteristics between active (AA) and controlled acromegaly (CA).

Methods: Cross-sectional study. BC was assessed by computed tomography (CT) at L3 vertebra (FocusedON-BC®), including tissue quantity (area, percentage and index) and quality by radiodensity (Hounsfield Units, HU) for skeletal muscle and adipose tissue compartments: visceral (VAT), subcutaneous (SAT), and intermuscular adipose tissue (IMAT). Further assessment included bioimpedance (Akern®), ultrasound (UProbeL6C®), handgrip strength (Jamar®), physical performance using the Short Physical Performance Battery (SPPB), and metabolic parameters including GH, IGF-1 and homeostatic model assessment of insulin resistance (HOMA-IR).

Results: 31 subjects were included (61.3% female, 53.3±10.5 years, BMI 27.5±4.3 kg/m²), with no baseline differences between groups. Subjects with AA (n=12) showed significantly higher basal IGF-1 (684 vs. 169 ng/mL; p< 0.001) and HOMA-IR (3.20 vs. 1.26; p=0.001). CA subjects exhibited higher VAT quantity (11.66% vs. 23.84%, p=0.002; 76.99 vs. 162.89 cm², p=0.011), as well as lower VAT and SAT radiodensity, indicating better adipose tissue quality with less fibrosis. A trend toward poorer physical performance was observed in AA subjects (SPPB 10.82±1.54 vs. 11.74±0.65; p=0.053). No significant differences were found in muscle mass, muscle strength, or most ultrasound and bioimpedance parameters.

Conclusion: AA was associated with lower VAT, poorer adipose tissue quality, greater insulin resistance, and a trend toward poorer physical performance compared to CA, despite similar muscle-related parameters. Advanced phenotyping may help better characterize the impact of disease activity on BC and metabolism in acromegaly.

Disclosure of Interest: None declared