PD1050 - CELL MEMBRANE CAPACITANCE SHOWS STRONGER DISCRIMINATION OF GLIM MALNUTRITION SEVERITY THAN PHASE ANGLE IN PANCREATIC AND UPPER GASTROINTESTINAL SURGICAL PATIENTS

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PD1050

CELL MEMBRANE CAPACITANCE SHOWS STRONGER DISCRIMINATION OF GLIM MALNUTRITION SEVERITY THAN PHASE ANGLE IN PANCREATIC AND UPPER GASTROINTESTINAL SURGICAL PATIENTS

M. F. Borges1,*, F. C. Borges1,2, L. Ferreira3, A. Alnatsha3, A. Sadanandam3, M. W. Büchler1

1Surgical Oncology, Botton-Champalimaud Pancreatic Cancer Centre, 2Faculdade de Medicina Universidade de Lisboa, 3Botton-Champalimaud Pancreatic Cancer Centre, Lisboa, Portugal

 

Rationale: The Global Leadership Initiative on Malnutrition (GLIM) criteria diagnose and classify malnutrition, but practical biomarkers reflecting this gradient remain limited. We aimed to evaluate whether cell membrane capacitance (CMC) discriminates GLIM severity better than phase angle.

Methods: In this single-centre prospective cohort study at a tertiary referral centre, 95 adults evaluated for pancreatic or upper gastrointestinal surgery underwent nutritional assessment and were classified by GLIM criteria as not malnourished, moderately malnourished, or severely malnourished. Separate ordinal logistic regression models were fitted for phase angle and CMC. Receiver operating characteristic analysis assessed discrimination for any malnutrition and severe malnutrition; optimal cutoffs were identified with Youden's J. Exploratory age-stratified analyses were also performed.

Results: Fifty patients (52.6%) were not malnourished, 27 (28.4%) moderately malnourished, and 18 (18.9%) severely malnourished. Higher phase angle was associated with lower GLIM severity (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.31-0.66; p<0.001). Higher CMC was also associated with lower GLIM severity (approximately OR 0.82 per 100-unit increase; p<0.001) and showed stronger discrimination for both any malnutrition (area under the curve [AUC] 0.820 vs 0.775) and severe malnutrition (AUC 0.815 vs 0.749). In exploratory age-stratified analyses, CMC remained independently associated with GLIM severity in both age groups.

Conclusion: Both phase angle and CMC were inversely associated with GLIM malnutrition diagnosis and severity. CMC showed stronger discrimination than phase angle and remained robust across age strata.

Disclosure of Interest: None declared