PT11. - UNVEILING THE IMPACT OF MATERNAL FISH INTAKE ON OFFSPRING METABOLITES AND INFLAMMATORY BOWEL DISEASE RISK DEVELOPMENT

PT11.

UNVEILING THE IMPACT OF MATERNAL FISH INTAKE ON OFFSPRING METABOLITES AND INFLAMMATORY BOWEL DISEASE RISK DEVELOPMENT

S. Ayten^1,*, G. Ciobotaru¹, F. Ottosson¹, M. Ernst², S. Frodi Olsen³, A. Ahrendt Bjerregaard⁴, Þ. Ingi Halldórsson⁵, T. Jess¹, M. Brusco De Freitas¹

¹ Department of Clinical Medicine, Aalborg University, Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), ²Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, ³Biobank, Congenital Disorders, and Vaccines Preparedness, Statens Serum Institut, ⁴Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁵Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland

Rationale: The impact of maternal fish and omega-3 intake on offspring metabolomics and inflammatory bowel disease (IBD) risk is unclear, however, it is important for guiding dietary recommendations in pregnancy.

Methods: This study used data from the Danish National Birth Cohort, focusing on 62 IBD cases and 58 control offspring metabolomics from dried blood spots and maternal fish intake data at gestational week 25. We applied regularized linear regression, using an 80:20 train-test split, to identify metabolites linked to different types of fish intake as well as omega-3 intake, selecting optimal parameters through cross-validation. We obtained R-squared values in the range between 0.04-0.21 for the test data.

Results: Among the 576 measured metabolites, we identified 59 metabolites related to at least one fish intake variable. Cox regression was used to examine associations between metabolites related to fish intake and IBD risk. In total, five of them were associated with the risk of developing IBD. 2,3-diphosphoglyceric acid, associated with higher total fish intake, was also linked to a reduced risk of IBD (HR = 0.69, p = 0.02). Trigonelline, associated with lower oily and total fish intake, and an amino acid metabolite linked to lower lean and total fish intake, were both related to an increased risk of IBD (HR=1.52, p=0.030, and HR=1.33, p=0.034, respectively). Conversely, an indole metabolite and an unknown metabolite, also linked to lower lean, oily, and total fish intake, were associated with a decreased risk of IBD (HR=0.65, p=0.03, and HR=0.56, p=0.02, respectively). 

Conclusion: We conclude from these exploratory analyses that fish consumption during pregnancy is related to a distinct metabolomic profile in the offspring that is associated with IBD and that specific metabolites may mediate a protective effect of maternal fish intake on the offspring`s risk of developing IBD.

Disclosure of Interest: None declared