PD962 - ASSOCIATION OF STRESS HYPERGLYCEMIA RATIO WITH MALNUTRITION, SARCOPENIA AND FRAILTY IN OLDER ADULTS: A LARGE RETROSPECTIVE COHORT STUDY

PD962

ASSOCIATION OF STRESS HYPERGLYCEMIA RATIO WITH MALNUTRITION, SARCOPENIA AND FRAILTY IN OLDER ADULTS: A LARGE RETROSPECTIVE COHORT STUDY

T. Kocaaslan^1,*, U. Balaban¹, O. Turhan², B. Kelleci Cakir¹, M. Esme², B. Balam Dogu², M. Gulhan Halil², M. Cankurtaran², C. Balci²

¹Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, ²Department of Internal Medicine, Division of Geriatrics, Hacettepe University Faculty of Medicine , Ankara, Türkiye

Rationale: The stress hyperglycemia ratio (SHR) is a biomarker of acute metabolic stress. In older adults, impaired metabolic stress responses may reflect reduced physiological reserve. Although malnutrition, sarcopenia, and frailty commonly coexist in geriatric populations, the clinical relevance of SHR remains unclear, particularly in outpatient settings. Therefore, this study aimed to examine the association between SHR and these geriatric syndromes in a large cohort of older adults.

Methods: This retrospective cross-sectional study included adults aged ≥65 years attending a geriatric outpatient clinic between January 2022-2026. Malnutrition, sarcopenia, and frailty scores were evaluated. SHR was calculated as admission glucose divided by estimated average glucose derived from HbA1c and categorized into quartiles. Univariable restricted cubic spline analyses were performed to explore potential nonlinear associations between SHR and geriatric outcomes.

Results: A total of 1,401 older adults were included (median age 73 years, IQR 69–78; 66% female). Restricted cubic spline analyses suggested a nonlinear association between SHR and the studied geriatric outcomes (Fig. 1). Polypharmacy was more frequent in the lowest and highest SHR quartiles (p<0.001). Indicators of geriatric vulnerability differed significantly: lower SHR levels were associated with poorer nutritional status (lower MNA-SF scores), higher sarcopenia risk (SARC-F), and higher frailty scores (CFS) (all p<0.001).

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Conclusion: Lower SHR was associated with poorer geriatric health indicators. Individuals in the lowest SHR quartile exhibited worse nutritional status, higher sarcopenia risk, and greater frailty compared with other groups. SHR may serve as a simple biomarker to help identify older individuals who may benefit from early functional and geriatric risk screening.

Disclosure of Interest: None declared