PD704 - TNFAIP8L1-INTEGRATED NOMOGRAM FOR POSTOPERATIVE SURVIVAL STRATIFICATION IN STAGE II-III COLON CANCER

PD704

TNFAIP8L1-INTEGRATED NOMOGRAM FOR POSTOPERATIVE SURVIVAL STRATIFICATION IN STAGE II-III COLON CANCER

Z. Li^1,*, S. Cao¹, Y. Zhou¹

¹Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China

Rationale: Prognostic heterogeneity remains substantial after curative resection for stage II-III colon cancer. We evaluated whether tumor TNFAIP8L1 expression could improve postoperative risk stratification when integrated with clinicopathological factors. 

Methods: We retrospectively analyzed 161 patients with stage II/III colon cancer who underwent surgical treatment at a single center. TNFAIP8L1 expression in resected tumor specimens was assessed by immunohistochemistry. Overall survival was analyzed using Kaplan-Meier and Cox regression methods. A nomogram was constructed from independent prognostic factors identified in the training cohort and internally validated in a randomly assigned validation cohort. 

Results: Low TNFAIP8L1 expression was associated with worse overall survival. Multivariable analysis identified tumor differentiation, log odds of positive lymph nodes, and TNFAIP8L1 expression as independent prognostic factors. The nomogram demonstrated a concordance index of 0.729 (95% confidence interval 0.672-0.786) in the training cohort and 0.729 (0.576-0.882) in the validation cohort. Calibration plots showed good agreement between predicted and observed survival, and decision curve analysis suggested potential clinical utility. 

Conclusion: TNFAIP8L1 is a favorable prognostic biomarker in stage II-III colon cancer. A nomogram integrating TNFAIP8L1, tumor differentiation, and log odds of positive lymph nodes may improve postoperative risk stratification, although external validation is required. 

Disclosure of Interest: None declared