PP230
METABOLIC SCORE FOR INSULIN RESISTANCE AND CHINESE VISCERAL ADIPOSITY INDEX IN RELATION TO DEPRESSION, SARCOPENIA, AND THEIR CO-OCCURRENCE AMONG CHINESE ADULTS AGED 50 AND OLDER: A PROSPECTIVE COHORT STUDY FROM CHARLS
C. Chen1,*, X. Shen1, W. Sun1, Q. Wu1
1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Rationale: Depression and sarcopenia frequently co-occur in aging populations and may share insulin resistance as a common metabolic underpinning, yet associations of non-insulin-based metabolic indices with both conditions remain unexplored within a unified framework.
Methods: This prospective cohort study included 3,648 participants aged ≥50 from the China Health and Retirement Longitudinal Study (2011–2015). Baseline METS-IR and CVAI served as exposures. Depression (CES-D-10 ≥10), sarcopenia (AWGS 2025 criteria), and their co-occurrence were assessed across three follow-up waves using generalized estimating equations, Firth penalized logistic regression, restricted cubic splines, and additive interaction analyses.
Results: After full adjustment, each interquartile-range increase in METS-IR and CVAI was associated with 12% and 15% lower odds of depression, and 86% and 82% lower odds of sarcopenia, respectively. Both indices showed strong inverse associations with co-occurring depression–sarcopenia (OR = 0.22 and 0.26, both P < 0.001). A significant synergistic additive interaction between low METS-IR and low CVAI was identified for sarcopenia (RERI = 6.24; attributable proportion = 0.51). Neither index meaningfully improved discrimination for depression alone (ΔAUC ≈ 0.003), whereas both substantially enhanced discrimination for sarcopenia (ΔAUC > 0.10).
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Conclusion: METS-IR and CVAI were inversely associated with sarcopenia and co-occurring depression–sarcopenia, with a synergistic interaction when both were jointly low. Their modest, largely overlapping associations with depression alone suggest distinct pathogenic pathways may underlie these outcomes. Studies with direct insulin measurements and clinical diagnostic assessments are needed to confirm these findings.
Disclosure of Interest: None declared