LB021 - THE TRIGLYCERIDE–GLUCOSE INDEX AND HYPERTENSION IN KOREAN ADULTS: GENETIC INSIGHTS INTO METABOLIC HETEROGENEITY

LB021

THE TRIGLYCERIDE–GLUCOSE INDEX AND HYPERTENSION IN KOREAN ADULTS: GENETIC INSIGHTS INTO METABOLIC HETEROGENEITY

X. Huang^1,*, M. Kim¹, M. Kim¹

¹Department of Food and Nutrition, Hannam University, Daejeon, Korea, Republic Of

Rationale: The triglyceride–glucose (TyG) index is a surrogate marker of insulin resistance associated with hypertension; however, its biological basis and subgroup-specific relevance remain unclear. This study examined the association between TyG index and hypertension and characterized the genetic and subgroup-specific determinants of TyG index in Korean adults.

Methods: In this cross-sectional study of 2,159 Korean adults, multivariable logistic and linear regression models were used to assess the association between TyG index and hypertension and cardiometabolic traits, with stratified analyses by age, body mass index (BMI), sex, diabetes, and dyslipidemia status. A genome-wide association study (GWAS) of the TyG index was conducted using the genotyped variants.

Results: The TyG index was independently associated with hypertension risk (adjusted odds ratio per 1-unit increase = 1.47, 95% confidence interval: 1.22–1.77), with a clear dose–response across TyG quartiles (P for trend < 0.001). The association was stronger in participants aged <50 years (P for interaction = 0.012) and tended to be stronger in those with BMI ≥25 kg/m² (P for interaction = 0.052). GWAS identified three genome-wide significant variants in the APOA5/ZPR1 region, among which two TyG-increasing APOA5 variants, rs662799 and rs2075291, were prioritized for downstream analysis. These variants were strongly associated with lipid traits but showed no significant association with glucose metabolism markers or a consistent positive association with hypertension.

Conclusion: The TyG index was independently associated with hypertension, particularly among younger and higher BMI participants. The identified genetic signal was predominantly lipid-related and centered on APOA5, suggesting that TyG reflects heterogeneous metabolic pathways rather than being a uniform marker of insulin resistance.

Disclosure of Interest: None declared