P164 - MULTIMODAL NUTRITIONAL AND PHYSICAL THERAPY FOR HOSPITAL-ACQUIRED SARCOPENIA: A 15-DAY INTERVENTION STUDY

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P164

MULTIMODAL NUTRITIONAL AND PHYSICAL THERAPY FOR HOSPITAL-ACQUIRED SARCOPENIA: A 15-DAY INTERVENTION STUDY

 

G. B. Yacoub1,*, D. Toledo Oliveira1, E. Giantomassi Paiva1, F. Antunes Ribeiro,1, J. Reginas Moraes1, J. Manoel Silva Jr1

1Hospital Israelita Albert Einstein, São Paulo, Brazil

 

Rationale: Sarcopenia in hospitalized patients correlates with prolonged stays and impaired recovery. This study evaluated a structured nutritional and rehabilitative protocol's efficacy, addressing gaps in current clinical practice

Methods: A prospective study enrolled 24 patients (16 men/8 women) with sarcopenia or risk (low handgrip strength + reduced muscle mass). The 15-day intervention combined: vitamin D (800 UI/day), omega-3 (2g/day), HMB (3g/day), caloric-protein adjustment (1.5g/kg/day), and daily motor physiotherapy. Primary outcome was muscle mass change (bioimpedance); secondary outcomes included handgrip strength (HGS) and Sarc-F score. 

 

 

 

 

 

Results: Significant improvements occurred in HGS (p<0.001, d=1.534) and muscle mass (p=0.021, d=1.108). Weight reduction (p=0.033) suggested metabolic optimization, while Sarc-F score decline (p=0.013) confirmed functional gains. Phase angle and BMI showed non-significant trends. Sex-based variations were observed, with men demonstrating greater absolute muscle mass improvements.

 

 

Conclusion:  This multimodal approach significantly enhanced muscle parameters, supporting its clinical implementation. While some metabolic measures require further study, the intervention's benefits for strength and functionality are clear. Cost-effectiveness analysis should guide broader adoption.

 

References: Aldrich L et al. J Cachexia Sarcopenia Muscle. 2025;16(1):e13662. doi:10.1002/jcsm.13662

Agoncillo M et al. Nutrients. 2023;15(20):4377. doi:10.3390/nu15204377

Su H et al. Front Med. 2024;11:1348212. doi:10.3389/fmed.2024.1348212

Disclosure of Interest: None declared