Sep 5, 2026
2:00 PM12:00 PM
ePoster display
PD839
VITAMIN D DEFICIENCY AS A NUTRITIONAL RISK FACTOR FOR MORTALITY IN METASTATIC PROSTATE CANCER PATIENTS
T. Cauz Valero1,*, I. Calvo Vázquez1, A. Hurtado Vázquez1, E. E. Herrera López1, A. Scavuzzo1, D. A. Pérez Camargo2, M. Á. Jiménez Ríos1
1Urologic Oncology, 2Oncology Nutrition, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico
Rationale: Vitamin D deficiency in prostate cancer has been correlated with increased tumor aggressiveness and oncologic outcomes but the relation with disease progression or mortality has not been entirely clear.
Methods: A retrospective cohort study was conducted in 149 patients with metastatic prostate cancer at Instituto Nacional de Cancerologia between 2019 and 2020. Serum vitamin D levels were measured and categorized as insufficient or deficient. Kaplan-Meier curves were used to compare survival outcomes. Multivariate model was employed to identify independent predictors of mortality.
Results: The multivariate analysis for mortality showed a significant association between vitamin D levels and greater risk of dead, with a threefold increase in risk when comparing groups (insufficiency vs. deficiency) (OR≈3.2; p=0.016). This result reminds consistent in alternative adjusted models (OR≈2.9; p=0.020). Age, oncologic diagnosis and nutritional diagnosis did not show significant associations. Kaplan-Meier was significant for mortality, not for progression, it occurs earlier in those with vitamin D deficiency.
Table 1. Baseline clinical characteristics and outcomes according to vitamin D status
Characteristic |
Insufficient (21–29 ng/mL) n=70 |
Deficiency (≤ 20 ng/mL) n=79 |
p-value | |
|
BMI (kg/m2) |
26.4 (23.4–29.0) |
26.91 (24.1–30.4) |
0.503 | |
|
Vitamin D (ng/mL) |
24.6 (22.0–27.0) |
15.0 (12.5–17.9) |
0.0001 | |
|
Age (years) |
70.0 (64.0–77.0) |
71.0 (66.5–77.5) |
0.541 | |
|
Progression-free survival (months) |
10.0 (6.0–18.0) |
9.0 (3.0–18.0) |
0.201 | |
|
Overall survival (months) |
24.5 (14.0–33.0) |
17.0 (9.0–29.0) |
0.032 | |
|
|
n (%) |
| ||
|
Disease progression No Yes |
32 (45.7) 38 (54.3) |
38 (48.1) 41 (51.9) |
0.771 | |
|
Vital status Dead Alive |
63 (90.0) 7 (10.0) |
62 (78.5) 17 (21.5) |
0.05 | |
Image:
Conclusion: Overall survival was shorter on vitamin D deficiency group, indicating a sustained effect of vitamin D on mortality. Early assessment and correction of vitamin D levels should be prioritized to improve patient survival.
Disclosure of Interest: None declared