PP159 - IMPACT OF PERSONALIZED NUTRITION ON RECOVERY AND NUTRITIONAL STATUS AFTER LAPAROSCOPIC DISTAL GASTRECTOMY WITH BILLROTH I

PP159

IMPACT OF PERSONALIZED NUTRITION ON RECOVERY AND NUTRITIONAL STATUS AFTER LAPAROSCOPIC DISTAL GASTRECTOMY WITH BILLROTH I

L. Jiaxuan^1,*, Z. Zhi¹, Z. Haiqiao¹, Z. Jun², Y. Jie¹

¹Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, ²Department of General Surgery, eijing Friendship Hospital, Capital Medical University, Beijing, China

Rationale: This study evaluated personalized versus traditional nutritional guidance to optimize post-discharge home management for gastric cancer patients.

Methods: This single-center RCT enrolled 142 patients discharged after laparoscopic radical distal gastrectomy. Patients were randomized (1:1) to personalized (n=71, individualized energy calculations) or traditional nutrition (n=71, routine education) group. The primary endpoint was weight loss at one month postoperatively. Secondary endpoints included skeletal muscle index (SMI) at six months, gastric half-emptying time, complications, target energy intake achievement, and EORTC-QLQ-C30 scores. Data underwent intention-to-treat analysis and binary logistic regression.

Results: At one month, the personalized group exhibited significantly lower median weight loss (1.50 vs. 3.00 kg, P<0.001) , reduced percentage weight loss (2.63% vs. 4.59%, P<0.001), and higher body mass index (22.05 vs. 20.87 kg/m², P=0.019). At six months, SMI was significantly better in the personalized cohort (P=0.025). Target energy intake achievement was markedly superior in the experimental group (90.14% vs. 76.06%, P=0.042). Overall complication rates (8.45% vs. 4.23%, P=0.493), gastric half-emptying time, and overall quality of life showed no significant intergroup differences. However, the personalized group reported significantly better appetite loss scores (P=0.004). Multivariate regression confirmed personalized guidance as an independent protective factor against >5% weight loss at one month (OR=0.233, 95% CI: 0.105-0.520, P<0.001).

Conclusion: Personalized nutrition  curtails early postoperative weight loss, preserves skeletal muscle mass, and enhances energy intake compliance without increasing perioperative complications. This intervention is an independent protective factor against severe malnutrition, demonstrating substantial clinical utility.

Disclosure of Interest: None declared