LB087 - THE TRIGLYCERIDE-GLUCOSE INDEX AS A MARKER OF INSULIN RESISTANCE: A FIRST EVALUATION IN THE LATVIAN POPULATION

LB087

THE TRIGLYCERIDE-GLUCOSE INDEX AS A MARKER OF INSULIN RESISTANCE: A FIRST EVALUATION IN THE LATVIAN POPULATION

G. Bilande^1,*, S. Ivanova ¹, M. Arisova¹, S. Skrebinska ¹, Z. Šmite¹, A. Fedulovs¹, J. Sokolovska¹

¹University of Latvia, Riga, Latvia

Rationale: Type 2 diabetes and obesity are major public health concerns with significant health and economic impacts. The triglyceride-glucose (TyG) index is a simple, cost-effective marker of insulin resistance with growing potential for risk assessment. However, its utility has not yet been studied in the Latvian population.

This study aimed to investigate the associations between glucose-triglyceride index, biochemical markers in individuals with overweight and obesity but without diabetes.

Methods: This cross-sectional study analysed data from Latvian residents participating in the PRAESIIDIUM study (ClinicalTrials.gov ID: NCT06195566). Anthropometric and laboratory data were collected from April 2024 until Feb 2025Participants were divided into two groups according to the size of the TyG index: <8.5 and >8.5, assuming that the group <8.5 is at low/medium risk, the group >8.5 is at high risk.

Results: Data from 77 participants (72.7% female) were analyzed, with a median age of 35.0 years and BMI of 28.5 kg/m². Participants with a high TyG index (n = 32) had significantly higher age, BMI, waist circumference, WHR, fasting glucose, C-peptide, triglycerides, LDL, remnant cholesterol, TG/HDL-C ratio, and liver enzymes (all p < 0.05). In the low TyG group, body weight strongly correlated with height (rs = 0.834), hip (rs = 0.787), and waist (rs = 0.732), and inversely with HDL (rs = –0.607), while hsCRP was positively associated with CRP, ceruloplasmin, and GGT (all p < 0.001). In the high TyG group, strong correlations were observed between weight and ALAT (rs = 0.746), and TG/HDL-C ratio with remnant cholesterol (rs = 0.618) and WHR (rs = 0.453); ceruloplasmin was linked to inflammatory markers but inversely related to hemoglobin, liver enzymes, and creatinine (all p < 0.05).

Conclusion: In the low TyG group, weight and waist circumference were strongly linked to body size, lipid levels, and mild inflammation markers. The high TyG group showed stronger associations between obesity measures, liver enzymes, inflammation, and insulin resistance indicators, reflecting greater metabolic disturbance. These results support the TyG index as a valuable tool to differentiate metabolic risk profiles in the population.

Disclosure of Interest: None declared