PP125 - THE RESTORE-DM STUDY: PRELIMINARY EFFECTS OF A NON-INDUSTRIALIZED-TYPE DIET ON GLYCEMIC CONTROL IN TYPE 2 DIABETES PATIENTS

PP125

THE RESTORE-DM STUDY: PRELIMINARY EFFECTS OF A NON-INDUSTRIALIZED-TYPE DIET ON GLYCEMIC CONTROL IN TYPE 2 DIABETES PATIENTS

L. C. V. Ribeiro^1,2, J. C. M. Godinho-Mota^1,2, L. M. Godoi^1,2, H. S. M. Teixeira^1,2, J. T. da Silva^1,2, C. M. Ciqueira^1,2, D. F. S. Ayala², W. K. S. Barroso³, S. Vêncio⁴, F. C. Corgosinho¹, A. Armet⁵, C. M. Prado⁵, J. Walter^6,7,8, J. F. Mota^1,2,*

¹School of Nutrition, ²NutriMetaBiome, ³Hypertension Unit, Federal University of Goiás, Goiânia, ⁴Institute of Pharmaceutical Sciences, Aparecida de Goiânia, Brazil, ⁵Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada, ⁶APC Microbiome Ireland, ⁷School of Microbiology, ⁸Department of Medicine, University College Cork, Cork, Ireland

Rationale: Type 2 diabetes (T2D) is a major risk factor for cardiometabolic diseases, and its lower prevalence in non-industrialized populations suggests a key role of diet. However, evidence-based dietary strategies in T2D remain limited, particularly those based on ancestral dietary patterns.

Methods: The RESTORE-DM study is an ongoing randomized, controlled, crossover trial evaluating a non-industrialized, anti-inflammatory diet in 30 individuals with T2D (BMI 25.0–39.9 kg/m²; HbA1c 6.0–10.0%). Participants receive the RESTORE diet or their habitual diet, followed by crossover after a ≥14-day washout; each intervention lasts 14 days. The RESTORE diet, inspired by Papua New Guinea dietary patterns, emphasizes minimally processed foods, high fiber (~45g/day), and exclusion of ultra-processed products. Meals are provided to meet estimated energy needs; patients maintain their usual diet during control. Glycemic outcomes are assessed by continuous glucose monitoring, and body composition, blood pressure, gastrointestinal tolerability are evaluated. Gut microbiome analyses are ongoing.

Results: Preliminary analyses (n=9) showed high adherence. Mean HbA1c was 7.26±1.32% and BMI 33.3±4.0 kg/m². RESTORE diet improved time in range (96.5±5.1% vs 72.3±41.1%,p<0.001), and tended to lower estimated HbA1c (6.1±0.3 vs 6.9±1.6%,p=0.053) compared to control. Body weight (-2.4±0.8kg), BMI (-0.9±0.3kg/m²), hip circumference (-3.3±2.0cm) decreased (p<0.01), with a trend for waist reduction (-1.9±2.0cm,p=0.059). Systolic blood pressure (-3.8±3.0mmHg) and fat mass (-1.1±1.0kg) decreased during RESTORE (p<0.05), without lean mass changes, compared to baseline. The diet was well tolerated, without significant differences in gastrointestinal symptoms.

Conclusion: A non-industrialized dietary pattern improves glycemic control and cardiometabolic parameters over a short period, with high tolerability in T2D.

Disclosure of Interest: None declared