P1048 - A PROSPECTIVE COHORT STUDY ON CHANGES IN NUTRITIONAL STATUS AND PHYSICAL FITNESS AFTER MULTIMODAL PERSONALIZED PREHABILITATION AMONG COLON CANCER PATIENTS UNDERGOING SURGERY

P1048

A PROSPECTIVE COHORT STUDY ON CHANGES IN NUTRITIONAL STATUS AND PHYSICAL FITNESS AFTER MULTIMODAL PERSONALIZED PREHABILITATION AMONG COLON CANCER PATIENTS UNDERGOING SURGERY

E. Valgaeren^1,2,*, N. Westra³, M. Holverda^1,2, N. Klaassen-Dekker⁴, D. E. Kok⁴, E. Kampman⁴, N. T. van Heek^4,5, R. M. Winkels⁴

¹Dietetics, Gelderse Vallei Hospital, ²Nutrition and Health Care Alliance, ³Physical Therapy, Gelderse Vallei Hospital, Ede, ⁴Human Nutrition and Health, Wageningen University & Research, Wageningen, ⁵Surgery, Gelderse Vallei Hospital, Ede, Netherlands

Rationale: Many hospitals implemented prehabilitation programs, but only few studies evaluated the results of prehabilitation programs in real life clinical practice. We assessed changes in nutritional status and physical fitness among Colon Cancer (CC) patients after supervised or unsupervised multimodal prehabilitation and explored clinical outcomes.

Methods: A prehabilitation program for CC patients was implemented in a general hospital. Screening at diagnosis (T0) determined if patients were fit or unfit and subsequently referred to respectively unsupervised or supervised prehabilitation. Being unfit was defined as severe malnutrition and/or low cardiorespiratory fitness (VO2max <18.2ml/kg/min). Follow-up measurements were conducted a week before (T1) and 6 weeks after (T2) surgery. Nutritional status was assessed by the Patient Generated Subjective Global Assessment Short Form, fat free mass (FFM) and protein intake. Physical fitness was evaluated through VO2max, handgrip strength (HGS), 5 times-sit-to-stand (5TSTS) test and maximal inspiratory pressure (MIP).

Results: In total, 90 CC patients were enrolled of whom 33% were unfit and followed supervised prehabilitation. Between T0 and T1 improvements in physical fitness were most pronounced in the supervised group, VO2max increased with 12%, HGS with 2%, 5TSTS with 14% and MIP with 19%. At T0, 32% of supervised and 42% of unsupervised patients reached the minimal recommended daily protein intake. This increased towards respectively 78% and 81% at T1 and 50% and 60% at T2. Physical fitness was better at T2 than at T0 in the supervised group. Nutritional status was better at T2 than at T0 in both groups.

Conclusion: Our findings indicate that personalised multimodal prehabilitation improves nutritional status and physical fitness before and after surgery in fit and unfit CC patients.

Disclosure of Interest: E. Valgaeren: None declared, N. Westra: None declared, M. Holverda: None declared, N. Klaassen-Dekker: None declared, D. E. Kok Grant / Research Support from: Danone Global Research & Innovation Center for investigator-driven studies, which are not directly related to the current work., E. Kampman: None declared, N. T. van Heek: None declared, R. M. Winkels: None declared