LB102 - OLIVE FRUIT EXTRACT PLUS HMB ATTENUATES EXHAUSTIVE EXERCISE-INDUCED STRENGTH LOSS AND MODULATES OXIDATIVE STRESS AND INFLAMMATORY RESPONSES IN OLDER ADULTS

LB102

OLIVE FRUIT EXTRACT PLUS HMB ATTENUATES EXHAUSTIVE EXERCISE-INDUCED STRENGTH LOSS AND MODULATES OXIDATIVE STRESS AND INFLAMMATORY RESPONSES IN OLDER ADULTS

S. L. Pereira^1,*, P. Pabla², M. Mohamed², J. M. Lopez-Pedrosa³, M. T. Garcia³, G. E. Baggs¹, K. Smith², B. E. Phillips², R. Rueda³, P. J. Atherton²

¹Abbott, Columbus, United States, ²Univ. Nottingham, Nottingham, United Kingdom, ³Abbott, Granada, Spain

Rationale: Older adults often exhibit delayed recovery after unaccustomed strenuous exercise, potentially due to increased inflammation and oxidative stress. This study evaluated the effects of olive fruit extract (OFE) combined with beta-hydroxy-beta-methylbutyrate (HMB) on exercise-induced strength loss, oxidative stress, and inflammation.

Methods: Twenty-eight healthy older adults (66.5 ± 4.1 years; BMI 25.2 ± 2.7; 16 men, 12 women) were randomized to receive 8 oz of either flavored water (placebo) or OFE (9 mg) + Ca-HMB (1.5 g) (OFE+HMB) daily for 4 weeks before, during, and 7 days after exhaustive eccentric leg exercise (EE). Isokinetic concentric knee extensor peak torque was measured pre-EE, and at 30 min, 3 h, days 1, 2, 3 and 7 post-EE. Baseline muscle cross-sectional area (CSA) (ultrasound) was used to normalize leg strength. Plasma markers were assessed at baseline, pre-EE, and post-EE (45 min, 1 d). Data are mean ± SEM. Strength was analyzed by ANCOVA (adjusted for sex, age, and pre-EE value); biomarkers by ANOVA with Tukey’s test.

Results: Both groups showed significant loss of normalized strength post-EE; however, OFE+HMB significantly attenuated strength loss and favored recovery: 30 min post-EE (−16.84 ± 3.68% vs. −28.48 ± 2.75% placebo; p=0.020); day 7 (2.95 ± 2.88% vs. −4.82 ± 3.73% placebo; p=0.081). Over the 4-week pre-EE to 1d post-EE period showing group x time interaction, OFE+HMB improved antioxidant capacity (Ferric reducing antioxidant power-FRAP, p=0.012), reduced oxidized LDL:LDL-cholesterol ratio (p=0.038), and lowered inflammation markers TNF-α (p=0.008) and IL-6 (p=0.033). IL-8 increased only in placebo post-EE (p=0.008).

Conclusion: In older adults, OFE+HMB supplementation attenuated post-exercise strength decline favoring recovery and favorably modulated oxidative stress and inflammatory profiles. 

Disclosure of Interest: S. Pereira Shareholder of: Abbott, P. Pabla: None declared, M. Mohamed: None declared, J. Lopez-Pedrosa Shareholder of: Abbott, M. Garcia Shareholder of: Abbott, G. Baggs Shareholder of: Abbott, K. Smith: None declared, B. Phillips Speakers Bureau of: Abbott , R. Rueda Shareholder of: Abbott, P. Atherton Grant / Research Support from: Abbott