P299 - RELATIONSHIP BETWEEN NUTRITIONAL STATUS AND NEUTROPENIA IN CANCER PATIENTS RECEIVING CISPLATIN-BASED CHEMOTHERAPY

P299

RELATIONSHIP BETWEEN NUTRITIONAL STATUS AND NEUTROPENIA IN CANCER PATIENTS RECEIVING CISPLATIN-BASED CHEMOTHERAPY

C. Ezzouitina^1,², F. Z. CHRAA^1,², R. Laraichi^1,², A. Lachgar¹, K. Nouni¹, H. El Kacemi¹, T. Kebdani^1,*, K. Hassouni¹

¹Radiotherapy, National Institute of Oncology, ²Mohammed V University, Rabat, Morocco

Rationale: Malnutrition is frequent among cancer patients and is known to affect immune function. Chemotherapy-induced neutropenia is a common and potentially serious complication that can lead to treatment delays, dose reductions, or infections.

This study aims to evaluate the association between nutritional status and the incidence of neutropenia in patients receiving cisplatin-based chemotherapy.

Methods: This prospective study was conducted between January and March 2025 at the National Institute of Oncology in Rabat. Cancer patients (head and neck, cervical, and lung cancers) scheduled for cisplatin-based chemotherapy were enrolled.

This prospective study was conducted between January and March 2025 at the National Institute of Oncology in Rabat. Cancer patients (head and neck, cervical, and lung cancers) scheduled for cisplatin-based chemotherapy were enrolled.

Nutritional status was assessed before treatment initiation using BMI, serum albumin, and the Subjective Global Assessment (SGA). Neutropenia was defined and graded according to CTCAE v5.0 and monitored at each chemotherapy cycle.

Results: Among 72 patients (mean age: 43.1 ± 10.4 years), 49% were classified as malnourished according to SGA. The incidence of grade 3–4 neutropenia was significantly higher in malnourished patients compared to well-nourished ones (38% vs. 14%, p = 0.01).

Serum albumin levels <35 g/L were also independently associated with a higher risk of neutropenia.

Malnourished patients had a higher rate of chemotherapy delays and hospital admissions for febrile neutropenia.

Conclusion: Poor nutritional status is significantly associated with increased risk of chemotherapy-induced neutropenia in patients receiving cisplatin. These findings highlight the need for early nutritional assessment and intervention to reduce hematologic toxicity and improve treatment tolerance.

Disclosure of Interest: None declared