P447 - LOW PHASE ANGLE MAY INDICATE A MORE ACTIVE AND ENDOSCOPICALLY SEVERE INFLAMMATORY BOWEL DISEASE

P447

LOW PHASE ANGLE MAY INDICATE A MORE ACTIVE AND ENDOSCOPICALLY SEVERE INFLAMMATORY BOWEL DISEASE

A. Vadarlis^1,*, T. Maris², M. G. Pramateftakis³, G. Germanidis⁴, M. Chourdakis¹

¹Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, ²Gastroenterology, General Hospital of Thessaloniki "G.Papanikolaou", ³Fourth Surgical Department, General Hospital of Thessaloniki “G. Papanikolaou“, School of Medicine, ⁴Division of Gastroenterology, First Department of Internal Medicine, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

Rationale: The role of clinical and endoscopical assessment is irreplaceable in Inflammatory bowel disease (IBD), a chronic relapsing condition including Crohn's disease (CD) and ulcerative colitis (UC). However, the need to develop non-invasive biomarkers to evaluate and monitor the disease course is increasing. This study aims to investigate the role of bioelectrical impedance analysis (BIA)-derived Phase angle (PhA), as a potential biomarker in IBD

Methods: This study included both hospitalized and outpatients diagnosed with CD or UC in two major IBD centers in Greece. Phase angle was measured through BIA (Bodystat Quadscan 4000 touch) under a strict protocol, whereas disease activity and endoscopic activity was evaluated through ileocolonoscopy, using validated widely-used scores. Statistical analysis was carried out with a statistical software

Results: A total of 144 patients with IBD (96 with CD and 48 with UC) participated in the study. The mean value of PhA was 5.9±1.2°. Statistically significant differences were observed between patients in remission (mean PhA=6.097±1.054) compared to active disease (mean PhA=5.14±1.063, p=0.009), as well as between patients with minimal endoscopically lesions (mean PhA=5.840±1.174) compared to endoscopically mild to severe disease (mean PhA=5.289±0.865, p=0.045). Patients with PhA values below the age, gender and BMI-standardized reference values had statistically significantly lower values of hematocrit (p=0.006), hemoglobulin (p=0.039), vitamin D (p=0.048), and higher C-reactive protein (p=0.048), and erythrocyte sedimentation rate (p=0.047)

Conclusion: Low PhA in IBD indicates a more active and endoscopically severe disease with increased inflammatory burden. These observations indicate that low PhA could be considered a poor prognostic factor in IBD. Further prospectively designed studies are needed to establish the prognostic role of PhA in IBD

Disclosure of Interest: None declared