P1045 - PREHABILITATION IN GI CANCER: SERUM CYTOKINES AND RELATIONSHIPS WITH NUTRITIONAL AND FUNCTIONAL STATUS

P1045

PREHABILITATION IN GI CANCER: SERUM CYTOKINES AND RELATIONSHIPS WITH NUTRITIONAL AND FUNCTIONAL STATUS

E. Finizio^1,*, A. Amedei¹, E. Russo¹, G. Nannini¹, E. Niccolai¹, S. Bertorello¹, G. D. Testa¹, G. Baldini¹

¹University of Florence, Florence, Italy

Rationale: Surgical interventions modify the structure and/or functionality of the human body, while the individual's
health, nutritional, functional, and psychological status may significantly influence postoperative outcomes. This study
examines pre-surgery cytokines’ levels in gastrointestinal cancer patients, to identify correlations with nutritional and
functional parameters.

Methods: Analysis included cytokine assays using the MixMatch Human kit, bioimpedance analysis with the BIA 101
BIVA® PRO, and muscle strength evaluation with the JAMAR®TM Plus+ dynamometer. Statistical comparisons of
cytokines’ values among patients’ groups were obtained using the Mann Whitney Test, while correlations between
cytokines and clinical parameters were assessed using the Spearman Rank Correlation Coefficient. Statistical significance was set at p≤0.05.

Results: Of the 37 patients enrolled, with an overall average age of 73.38 years (range 56-90), 97.30% had
gastrointestinal oncological diseases. It was observed that MIP-1β levels were significantly higher in patients with FMI
(Fat Mass Index) values beyond the normal cut-off values (p = 0.0005). Moreover, considering the entire sample, MIP-1β
positively correlated with current weight (rho = 0.470, p = 0.0033), body mass index (rho = 0.402, p = 0.01), and FMI (rho
= 0.524, p = 0.0008), while having a negative correlation with total body water percentage. Additionally, the concentration
of MIP-1β and IFN-γ was significantly elevated among patients within the BMI range of 30-34.99 kg/m2.

Conclusion: These findings suggest an inflammatory state associated with excess fat mass, potentially worsening
surgical outcomes in oncological patients. The nutritional intervention in the multimodal Prehabilitation pathway should
target both an increase of muscle mass and a reduction of fat mass, enhancing the inflammatory balance.

Disclosure of Interest: None declared