PD760 - EVALUATION OF THE EFFECTS OF DIETARY FIBER INTAKE ON THE TREATMENT PROCESS IN PATIENTS AGED 2-18 YEARS UNDERGOING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

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PD760

EVALUATION OF THE EFFECTS OF DIETARY FIBER INTAKE ON THE TREATMENT PROCESS IN PATIENTS AGED 2-18 YEARS UNDERGOING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

F. E. Sezer-Karatas1,*, G. Baysoy2

1Nutrition and Dietetic, 2Pediatric Gastroenterology, Istanbul Medipol University, Istanbul, Türkiye

 

Rationale: This study aimed to assess the effects of fiber intake on treatment-related side effects and quality of life in pediatric HSCT patients.

Methods: The study was conducted with 33 children aged 2–18 years. Patients undergoing HSCT were evaluated during hospitalization, transplantation, engraftment, and post-treatment periods. The intervention group met daily fiber requirements from hospitalization, while the control group continued normal nutritional treatment. Demographic and pre-transplant dietary data were collected, and the Pediatric Quality of Life Inventory (PedsQL 4.0), Gastrointestinal Symptom Rating Scale (GSRS) and Common Terminology Criteria for Adverse Events (CTCAE v5.0) were administered.

Results: Post-treatment GSRS scores were lower in the study group (18.0) than in the control group (23.5) (p<0.05). Abdominal pain (4) and diarrhea (5) scores were also lower than those of the control group (5 and 6.5, respectively) (p<0.05). In the control group, PedsQL scores of children (from 1750.0 to 1500.0) and parents (from 1600.0 to 1387.5) decreased significantly after treatment compared to hospitalization (p<0.05). Diarrhea, oral mucositis, nausea, and vomiting were common in both groups. Bloating was higher during transplantation in the study group (35.3%) (p<0.05). Energy and nutrient intakes exceeded RDA in the study group, whereas vitamin D intake was insufficient in the control group (34.23%) (p<0.001). Fiber intake was negatively correlated with abdominal pain (r=-0.377) and indigestion (r=-0.421), and positively correlated with quality of life (r=0.418) (p<0.05).

Conclusion: Fiber intake showed a positive effect on some gastrointestinal symptoms and may help improve quality of life after treatment. Increased gastrointestinal symptom severity after treatment was associated with reduced quality of life in children and parents.

Disclosure of Interest: None declared