P410 - CHANGE IN MUSCLE MASS USING MUSCLE CIRCUMFERENCE IN CRITICALLY ILL PATIENTS AT THE INTENSIVE CARE UNIT: A SINGLE CENTER STUDY

P410

CHANGE IN MUSCLE MASS USING MUSCLE CIRCUMFERENCE IN CRITICALLY ILL PATIENTS AT THE INTENSIVE CARE UNIT: A SINGLE CENTER STUDY

I. K. Zapanta^1,*, G. C. Paguia¹, D. C. R. Samin¹, R. A. J. Pingol¹, K. I. B. Aldana¹, C. F. C. De Vera¹

¹Weight Intervention and Nutrition Services, St. Luke's Medical Center, Quezon City, Philippines

Rationale: Critically ill patients are at risk of developing sarcopenia which can result to negative clinical outcomes. This study aimed to evaluate of muscle loss in critically ill patients admitted in the intensive care unit by measuring muscle circumference and determining the factors associated with changes in muscle mass.

Methods: A single-center prospective observational study was conducted with adult, newly-admitted patients in the intensive care unit. The mid-upper and calf circumference were measured on Day 0, 7, 14, and 28 of hospital stay. Data on age, sex, BMI, energy and protein adequacy, SOFA score, referral to nutrition team, and referral to rehabilitation medicine were obtained to determine association with change in muscle circumference. The mean percentage change in muscle circumference were calculated along with univariate statistical analysis to determine association. Level of significance was set at α = 0.05.

Results: There was an average of -1.7% muscle loss in the first 7 days (-0.24% per day) of critical illness gradually escalating to -4.6% by day 28. The average amount of energy delivered is 23.6 kcal/kg/day (1432 ± 300 kcal) while protein delivered is 0.9 g/kg/day (57.9 ± 22.4 g protein). There was no significant association found between muscle loss and factors such as age, sex, BMI, energy and protein adequacy, SOFA score, and referrals to nutrition and rehabilitation medicine teams. 

Conclusion: This study marks the first investigation in the Philippines to quantify muscle mass loss among critically-ill patients during hospitalization. Results reveal a continuous decline in muscle mass, at a rate of -0.24% per day within the first 7 days of ICU stay. No significant associations pertaining to muscle loss were found. Nonetheless, a progressive significant decrease in muscle circumference persisted until the 28th day of follow-up.

Disclosure of Interest: None declared