P456 - COMBINING THE SUBJECTIVE GLOBAL ASSESSMENT WITH STANDARDIZED PHASE ANGLE TO PREDICT MORTALITY IN PATIENTS WITH ADVANCED CIRRHOSIS

P456

COMBINING THE SUBJECTIVE GLOBAL ASSESSMENT WITH STANDARDIZED PHASE ANGLE TO PREDICT MORTALITY IN PATIENTS WITH ADVANCED CIRRHOSIS

B. S. Rocha¹, L. R. Anastácio², L. G. Ferreira³, Y. G. G. Mizubuti², S. C. Ferreira⁴, M. I. T. D. Correia⁵, B. Chaves Santos^2,*

¹Nutrition Department, ²Food Science Graduate Program, Universidade Federal de Minas Gerais, Belo Horizonte, ³Nutrition and Health Graduate Program, Universidade Federal de Lavras, Lavras, ⁴Food, Nutrition, and Health Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, ⁵Surgery Graduate Program, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Rationale: The Subjective Global Assessment (SGA) is a validated tool to diagnose malnutrition in patients with cirrhosis. Since the standardized phase angle (SPA) is an objective parameter associated with muscle quality, adding the classification of low SPA to the diagnosis of malnutrition by the SGA could be more effective to predict negative clinical outcomes in this population.

Methods: This is an observational prospective study including adult patients with cirrhosis undergoing evaluation for liver transplant in a Brazilian public hospital. The assessment was carried out between 2011 and 2024, and included the SGA as well as bioelectrical impedance analysis to obtain the SPA. Low SPA was classified when the values were ≤ -1.6. The occurrence of death up to one year after the assessment was verified in the electronic medical records. The combination of malnutrition and low SPA (SGA B/C+SPA) was tested in adjusted Cox regression models.

Results: We included 198 patients (53 [47-60] years, 69.7% male, 52% Child-Pugh B). According to SGA, 68.2% of the patients were malnourished. Median SPA was -2.21 (-3.01 - -2.17), and 69.7% of the sample had low SPA. The majority of patients (54%) had both malnutrition by SGA and low SPA. Thirty-one patients died within a year, and 71% of them had SGA B/C+SPA. SGA B/C+SPA was an independent predictor of mortality (HR: 2.5; CI: 1.1-5.6; p=0.026).

Conclusion: SGA B/C+SPA can be an alternative to identify patients with advanced cirrhosis with an increased risk of mortality.

Disclosure of Interest: None declared