PD722 - MORPHOFUNCTIONAL ASSESSMENT AS A KEY TOOL IN THE EVALUATION OF CANCER-RELATED MALNUTRITION

PD722

MORPHOFUNCTIONAL ASSESSMENT AS A KEY TOOL IN THE EVALUATION OF CANCER-RELATED MALNUTRITION

N. Y. Wu-Xiong¹, B. Alabadí-Pardiñes², M. J. López³, M. E. Arjonilla³, E. Sánchez Navarro³, A. Jiménez⁴, C. Mañas⁴, J. Ruiz⁴, R. Fernández Jiménez⁵, I. Gonzalo Montesinos^6,*, J. M. García Almeida⁵ on behalf of Anyvida Group

¹Department of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, ²Department of Endocrinology and Nutrition, INCLIVA Biomedical Research Institute, Valencia, ³Department of Endocrinology and Nutrition, Hospital General Universitario Morales Meseguer, Murcia, ⁴Department of Endocrinology and Nutrition, Hospital General Universitario de Valencia, Valencia, ⁵Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, Málaga, ⁶Department of Endocrinology and Nutrition, Hospital Universitario de Fuenlabrada, Madrid, Spain

Rationale: Early identification of malnutrition severity in cancer patients remains a clinical challenge. While tools such as the Subjective Global Assessment(SGA) and Global Leadership Initiative on Malnutrition(GLIM) criteria are widely used, the diagnostic performance of morphofunctional parameters requires further evaluation.Analyze the association between morphofunctional parameters and GLIM and SGA criteria according to malnutrition severity, as well as their complementary clinical value.

Methods: A cross-sectional analysis was performed in cancer patients with available morphofunctional data.ROC curves were constructed for bioelectrical impedance phase angle(BIA pHA), rectus femoris cross-sectional area(RF-CSA), and handgrip strength(HGS), stratified by sex. Area under the curve(AUC), sensitivity, specificity, and optimal cut-off points(Youden index) were calculated for both SGA and GLIM classifications.

Results: The study included 518 cancer patients.We identified cutoff points in men, in relation to the SGA criteria for moderate and severe malnutrition, as follows: BIA pHA of 4.65º, RF-CSA of 3.39cm², and HGS of 29.17kg. In women, the cutoff points were a BIA pHA of 4.55º and a RF-CSA of 2.84cm². These results were statistically significant.Regarding cutoff points using the GLIM criteria for moderate and severe malnutrition, in men a cutoff point was observed in the RF-CSA of 3.47cm². In women, cutoff points were found for BIA pHA of 4.06º, RF-CSA of 2.81cm², and HGS of 21.5kg. These results were statistically significant.

Conclusion: We identified cutoff points for BIA pHA in relation to moderate and severe malnutrition according to GLIM criteria, as well as for RF-CSA in both sexes. In women, a cutoff point was also obtained for HGS. However, when analyzed using SGA criteria, cutoff points were found in women for BIA pHA, RF-CSA, and HGS, whereas in men they were only identified for RF-CSA.

Disclosure of Interest: None declared