LB081 - ELECTROLYTE DISTURBANCES IN HOSPITALIZED CHINESE PATIENTS WITH HEMATOLOGIC MALIGNANCIES AND ITS IMPACT ON CLINICAL OUTCOMES: A RETROSPECTIVE OBSERVATIONAL STUDY

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LB081

ELECTROLYTE DISTURBANCES IN HOSPITALIZED CHINESE PATIENTS WITH HEMATOLOGIC MALIGNANCIES AND ITS IMPACT ON CLINICAL OUTCOMES: A RETROSPECTIVE OBSERVATIONAL STUDY

X. Zhang1,*, H. Liu2, H. Xie3, L. Zhou4, X. Ma5, M. Zhang6, Y. Qiu7, Y. Xiang8, H. Cui9, X. Chen10, H. Liu11, J. Xu12, Y. Liu13, R. Xu14

1Clinical Nutrition, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 2Clinical Nutrition, the Third XiangYa Hospital，Central South University, Changsha, 3Clinical Nutrition, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 4Clinical Nutrition, The Third Affiliated Hopital of Kunming Medical University, Yunnan Center Hospital, Peking University Cancer Hospital Yunnan, Kunming, 5Clinical Nutrition, Lu'an Hospital, Anhui Medical University, Lu'an , 6Clinical Nutrition, Peking University Shenzhen Hospital, Shenzhen, 7Clinical Nutrition, Nantong First People's Hospital, Nantong, 8Clinical Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 9General Surgery, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 10Clinical Nutrition, Nan Jing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 11Clinical Nutrition, Weifang People’s Hospital, Weifang, 12Clinical Nutrition, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 13Clinical Nutrition, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu, 14Clinical Nutrition, Renji Hospital, Shanghai Jiao Tong University, School of Medicine;College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

 

Rationale: Electrolyte disturbances (EDs) are common in hematologic malignancies, but its impact remains unclear. We evaluated associations between severe EDs and in-hospital mortality and length of stay (LOS) in a multicenter Chinese cohort.

Methods: We included 2,801 adult hematologic malignancy patients from 13 Chinese hospitals. Severe EDs were defined as ≥2 serum electrolyte abnormalities. Binary logistic and multivariate linear regression were used, adjusting for Charlson Comorbidity Index, tumor subtype, liver/renal function, anemia, hypoalbuminemia, inflammation, and interaction terms (age, sex).

Results: Of 2,801 patients, 88.1% had ≥1 electrolyte abnormality. After full adjustment, severe EDs were independently associated with increased mortality only in females (OR 5.34, 95% CI 1.86–15.37, p=0.01) and younger patients (<65 years, OR 2.45, 95% CI 1.15–5.22, p=0.01); no association in males or older patients (p for interaction=0.01). For LOS, severe EDs were associated with prolonged stay (β=1.49 days, 95% CI 0.08–2.90, p=0.04), more pronounced in females (β=2.14days, 95% CI 0.54–3.74, p=0.01) and younger patients (β=1.84days, 95% CI 1.12–3.56, p=0.04), but not in males or older patients.

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Conclusion: In hospitalized hematologic malignancy patients, the impact of severe EDs on mortality and LOS was modified by age and sex. EDs were independent risk factors for adverse outcomes in younger and female patients, with effect likely attenuated in older and male patients due to higher competing mortality. These findings support demographic-specific electrolyte management.

References: Li Y, Chen X, Shen Z, Wang Y, Hu J, Xu J, Shen B, Ding X. Electrolyte and acid-base disorders in cancer patients and its impact on clinical outcomes: evidence from a real-world study in China. Ren Fail. 2020 Nov;42(1):234-243. 

 

Disclosure of Interest: None declared