Sep 14, 2025
1:00 PM2:00 PM
Poster Session
P359 - MACRONUTRIENT OXIDATION: IMPACT OF PHYSICAL ACTIVITY AND POLYMORBIDITY IN CANCER PATIENTS
P359
MACRONUTRIENT OXIDATION: IMPACT OF PHYSICAL ACTIVITY AND POLYMORBIDITY IN CANCER PATIENTS
P. S. Barcellos1,2,*, M. Lemos-Araujo3, D. M. Linhares-Sousa1, N. P. G. F. B. Borges2, D. P. M. Torres2
1DCF, UFMA, São Luís, Brazil, 2FCNAUP, Porto University, Porto, Portugal, 3DEF, UFMA, São Luís, Brazil
Rationale: Changes in energy metabolism are a common phenomenon in cancer patients. This study aimed to evaluate the influence of Physical Activity (PA) and polymorbidity on energetic compounds measured by indirect calorimetry (IC).
Methods: Cancer patients (49) from Hospital São João, Portugal, were classified by regular PA before hospitalization and presence or absence of polymorbidity (ESPEN criteria). Energetic compounds were measured by IC (Cosmed k4 b2). Statistical analyses were presented, including descriptive analysis and the Mann-Whitney U test (SPSS Software).
Results: Table 1: Energetic compounds by indirect calorimetry in patients who exercised regularly before hospitalization and polymorbids patients.
Physical Activity |
Polymorbidity | ||||||||
|
|
Yes |
No |
P-value |
Total |
Yes |
No |
P-value |
Total | |
|
N |
26 |
23 |
|
49 |
33 |
16 |
|
49 | |
|
VO2 (L/min) |
0.30±0.09 |
0.23±0.07 |
0.018* |
0.27±0.09 |
0.26±0.08 |
0.28±0.01 |
0.430 |
0.27±0.09 | |
|
VCO2 (L/min) |
0.24±0.07 |
0.18±0.05 |
0.005* |
0.21±0.07 |
0.21±0.07 |
0.23±0.08 |
0.267 |
0.21±0.07 | |
|
Giucose Oxidation Rate (g/min) |
0.16±0.10 |
0.09±0.73 |
0.015* |
0.12±0.09 |
0.11±0.09 |
0.15±0.08 |
0.127 |
0.12±0.09 | |
|
Glucose Oxidating (g) |
4.84±3.01 |
2.77±2.21 |
0.015* |
3.87±2.84 |
3.49±2.90 |
4.65±2.61 |
0.125 |
3.87±2.84 | |
|
Fat Oxidation Rate (g/min) |
0.08±0.05 |
0.07±0.04 |
0.471 |
0.08±0.04 |
0.09±0.04 |
0.06±0.04 |
0.044* |
0.08±0.04 | |
|
Fat Oxidation (g) |
2.68±1.63 |
2.37±1.26 |
0.465 |
2.54±1.46 |
2.84±1.48 |
1.91±1.25 |
0.041* |
2.54±1.46 | |
*P-value = 0.05 Mann-Whitney U test
Conclusion: PA was able to increase VO2, VCO2, and Glucose Oxidation Rate. Meanwhile, the presence of polymorbidity increased lipid oxidation (Fat Oxidation Rate and Amount Fat Oxidation), suggesting the use of fat as an energy source. These findings reinforce the need for individualized nutritional strategies ensuring positive nutritional balance and supply of substrates to prevent malnutrition.
References: Barcellos, P. S., N. D. S. Fontinelle, N. J. P. Junior, N. P. G. F. B. Borges and D. P. M. Torres (2023). "Energy expenditure in polymorbid patients." Clinical Nutrition ESPEN 58: 522-523.
Disclosure of Interest: None declared