PD694 - MORPHOFUNCTIONAL DIFFERENCES ACCORDING TO AGE IN PATIENTS WITH CANCER: A COMPARATIVE ANALYSIS BETWEEN PATIENTS AGED <65 AND ≥65 YEARS

PD694

MORPHOFUNCTIONAL DIFFERENCES ACCORDING TO AGE IN PATIENTS WITH CANCER: A COMPARATIVE ANALYSIS BETWEEN PATIENTS AGED <65 AND ≥65 YEARS

B. F. Rodriguez Montalvan^1,*, M. J. Chinchetru Ranedo¹, S. Lanes Iglesias², H. Rendon Barragan³, M. T. Yeregui Balda³, C. Fernandez Lopez⁴, B. De Leon Fuentes⁴, E. Diego Perojo⁴, R. Fernandez Jimenez⁵, I. Gonzalo Montesinos⁶, J. M. Garcia-Almeida⁵ on behalf of Anyvida Group

¹Endocrinologia y Nutricion, Hospital Universitario San Pedro, ²Endocrinologia y Nutricion, Hospital Universitario San Pedro, Logroño, ³Nutricion, Hospital Universitario de Navarra, Pamplona, ⁴Endocrinologia y Nutricion, Hospital Universitario Cruces, Bilbao, ⁵Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Malaga, ⁶Endocrinologia y Nutricion, Hospital Universitario de Fuenlabrada, Madrid, Spain

Rationale: Management of patients with cancer should be guided by physiological age and functional status rather than chronological age alone. Morphofunctional assessment is a key component of comprehensive evaluation, although its behaviour across age groups remains unclear.

Methods: Observational study including 518 oncology patients with malnutrition diagnosed according to GLIM criteria. Patients were stratified into two groups: ≥65 years (n=325) and <65 years (n=193). Anthropometric parameters, body composition by bioimpedance, muscle ultrasound, and functional performance tests were assessed.

Results: No significant differences were found in BMI, fat mass, or fat-free mass. However, geriatric patients showed a significantly less favourable morphofunctional profile, with lower phase angle (4.62±0.77 vs 5.11±0.85°; p<0.001) and lower body cell mass (22.13±5.66 vs 24.20±6.89 kg; p<0.001). Muscle ultrasound showed a smaller rectus femoris cross-sectional area in geriatric patients (3.31±1.31 vs 3.90±1.57 cm²; p<0.001). Functionally, performance was worse in TUG (10.4±4.03 vs 8.67±4.16 s; p<0.001), 5STS (14.3±5.31 vs 12.33±5.35 s; p<0.001), 30-second squat test (11.2±4.47 vs 13.5±5.30 repetitions; p<0.001), and handgrip strength (23.7±9.71 vs 27.72±12.14 kg; p<0.001). Phase angle was the variable most strongly associated with belonging to the geriatric group (r=-0.30)

Conclusion: Geriatric age is associated with significant morphofunctional impairment in cancer patients, including poorer electrical parameters, reduced cellular and muscle mass, smaller muscle area, and worse functional performance. These findings support incorporating morphofunctional assessment into routine evaluation to improve risk stratification and guide personalised interventions.

References: Huynh K, Zuvela J,et al. Management of malnutrition in older adults with cancer. Curr Opin Clin Nutr Metab Care. 2026;29(1):35-44

Disclosure of Interest: None declared