PD808 - IMPACT OF NUTRITIONAL STATUS ON OUTCOMES IN PATIENTS WITH HEAD AND NECK CANCER

PD808

IMPACT OF NUTRITIONAL STATUS ON OUTCOMES IN PATIENTS WITH HEAD AND NECK CANCER

M. Arnoriaga-Rodríguez^1,*, A. Bielza González¹, M. L. Carrascal Fabián¹, T. Hernández Hernández¹, B. Rodríguez Herrera¹, C. Serrano Moreno¹, I. Bretón Lesmes¹, C. Velasco Gimeno¹, M. L. Motilla de la Cámara¹, C. Cuerda Compés¹

¹Nutrition Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Rationale: Patients with head and neck cancer (HNC) are at high risk of malnutrition, especially during treatment with radiotherapy (RT) or chemoradiotherapy (CRT). Our aim was to assess the nutritional status of patients with HNC before and after treatment and to investigate its relationship with outcomes. 

Methods: This is a prospective study of patients with HNC with a baseline (V1) and a 2 weeks after treatment (V2) visits. A morphofunctional evaluation (anthropometry, bioimpedance, dynamometry, muscle and abdominal ultrasound, dysphagia screening (EAT-10)) was performed in each visit. Malnutrition was diagnosed based on GLIM criteria. Oncological treatments, nutritional support and complications were recorded.

Results: Twenty-six patients were recruited (66 [57–73.5] years, 65.4% males). The most frequent tumor sites were the oral cavity (46.2%) and pharynx (23.1%). Prescribed treatment was CRT (53.8%) or RT (46.2%). At V1, patients already showed a weight loss of 8.8%, increasing to 13.8% at V2, with a reduction in fat mass (26.5% vs 23.2%), an increase in fat-free mass (72.9% vs 75.2%) and total body water (53.2% vs 55.5%), and worsening dysphagia (EAT-10: 2.5 vs 14). Malnutrition remained high without significant changes (73.1% vs 81.8%). Nutritional supplementation was provided to 80.8% of patients. The most frequent complications were mucositis (73%), radiodermatitis (73%), anorexia (42%), and dysphagia (27%). In the regression analysis, CRT treatment was linked to anorexia (OR=20.3, p=0.011), adipose tissue muscle ultrasound with dysphagia (OR=1.3, p=0.043) and initial body mass index with emergency department visits (OR=1.2, p=0.046). 

Conclusion: Patients with HNC present a high prevalence of malnutrition and treatment-related complications. Longitudinal morphofunctional assessment is essential to identify factors associated with toxicity and represents a key tool for guiding personalized nutritional interventions.

Disclosure of Interest: M. Arnoriaga-Rodríguez: None declared, A. Bielza González Grant / Research Support from: Dietician contract funded by Nestle, M. L. Carrascal Fabián: None declared, T. Hernández Hernández: None declared, B. Rodríguez Herrera: None declared, C. Serrano Moreno: None declared, I. Bretón Lesmes: None declared, C. Velasco Gimeno: None declared, M. L. Motilla de la Cámara: None declared, C. Cuerda Compés: None declared