P799 - COFFEE INTAKE AND THE VASOPRESSIN SYSTEM - A COMBINED EPIDEMIOLOGICAL AND EXPERIMENTAL STUDY

P799

COFFEE INTAKE AND THE VASOPRESSIN SYSTEM - A COMBINED EPIDEMIOLOGICAL AND EXPERIMENTAL STUDY

F. Schill^1,2,*, S. F. Enhörning^1,3, S. Timpka^1,4, O. F. Melander^1,3, S. F. Hellstrand¹

¹Department of Clinicial Sciences, Lund University, ²Department of Cardiology, ³Department of Internal Medicine, ⁴Department of Obstetrics and Gynecology, Skånes Universitetssjukvård, Malmö, Sweden

Rationale: Even though coffee is suggested to have effecs on body hydration status, wheter the body fluid regulator vasopressin is affected by coffee intake is not known. The goal of this study was to investigate the possible links between coffee intake on vasopressin concentration. 

Methods: In the population-based cross-sectional Malmö Offspring Study (n=3270) we investigated the association between coffee intake and plasma concentration of the vasopressin surrogate marker copeptin by linear regression analyses. The analyses were adjusted for age and sex, for creatinine, HDL, LDL, triglycerides, glucose, systolic blood pressure, body mass index and smoking, and subsequently for drinking water intake and total fluid intake, respectively. Moreover, in an experimental study (n=26), we compared plasma copeptin after intake of 4 dL of coffee and 10 ml of water (as control). Median plasma copeptin concentrations were compared with the baseline value for both groups. The change from baseline was tested by Wilcoxon paired test. 

Results: Higher coffee intake was in the population associated with lower copeptin concentration after adjustment for co-variables including drinking water intake and total fluid intake. In the coffee experiment, acute intake of 4 dL of coffee significantly lowered copeptin concentration at all time points as when compared with baseline concentration. Ingestion of 10 ml of water also resulted in a slight copeptin reduction within 2 hours.

Conclusion: Our findings suggest that copeptin concentration is lower among individuals with high coffee consumption and that copeptin concentration can be reduced acutely by coffee intake. The mechanisms behind the coffee-induced copeptin reduction may involve oral and gut reflexes, volume load and/or specific effects of coffee compounds.

Disclosure of Interest: None declared