Sep 5, 2026
4:00 PM5:30 PM
Online
Oral Communication
Oral Communications II: New Perspectives on Nutrition, Aging and Chronic Disease
Jürgen BAUER
O012 - DOES AN OMEGA-3 POLYUNSATURATED FATTY ACIDS-ENRICHED DIET HAVE AN EFFECT ON CHANGE IN INDEPENDENCE IN NURSING HOME RESIDENTS? THE PROSPECTIVE RANDOMIZED CONTROLLED TRIAL MAIA
O012
DOES AN OMEGA-3 POLYUNSATURATED FATTY ACIDS-ENRICHED DIET HAVE AN EFFECT ON CHANGE IN INDEPENDENCE IN NURSING HOME RESIDENTS? THE PROSPECTIVE RANDOMIZED CONTROLLED TRIAL MAIA
R. Thibault1,2,*, E. Bajeux3, G. Mairesse4, Y. Gallien3, B. Anato3, K. Charras5, V. Rioux6, P. Legrand7, M. Abbas8, R. Le Bouquin-Jeannès8, P. Weill9, D. Somme10 on behalf of MAIA investigators group
1NuMeCan, Nutrition Metabolisms and Cancer, INRAE, INSERM, Univ Rennes, 2Endocrinology-Diabetology-Nutrition, 3Public Health, CHU Rennes, Rennes, 4Valorex, Combourtillé, 5Living Lab Geriatrics, CHU Rennes, 6Institut Agro Rennes-Angers, Rennes, France, 7Biochemistry, Institut Agro Rennes-Angers, 8LTSI, univ Rennes, Rennes, 9BleuBlancCoeur, Combourtillé, 10Geriatrics, CHU Rennes, univ Rennes, EHESP, Rennes, France
Rationale: N-3 polyunsaturated fatty acids (PUFAs) have nutritonal benefits, but with limited evidence in nursing home (NH) residents. Primary aim: to evaluate if n-3 PUFAs-enriched diet can slow down the ndependence decline in older NH residents.
Methods: Design: prospective, cluster-randomized, controlled, open-label, multicenter trial. 18 NH randomized in 2 groups: intervention = n-3 PUFAs enriched diet (O3), control = usual institutional diet (CTRL). Primary judgment criterion: Activities of Daily Living-Long Form Score (ADL-LFS) at month (M) 24. Secondary outcomes: nutritional status, fall, infections, cognition (MoCA), depression (Hamilton), omega index (OI) (% blood FAs), healthcare resource use. Statistics: multivariable linear mixed model adjusted; regression coefficients for the interaction group / time.
Results: 315 patients included: n=184 (O3), n=131 (CTRL). 87.5±7.3 yr, BMI 26.2±4.9, M/F 92/223, GIR, 3.9±1.0, sarcopenia 178/308 (58%), malnutrition 193/315 (61%), death 102/315 (32%) . At M24 (N=201), ADL-LFS changed from 2 [0-6] to 9 [2-14] (O3), 3 [0-7] to 6 [3-14] (CTRL) (Pinteraction = 0.7). at M24, phase angle increased (P=0.002) in O3 but not fat-free mass index (P=0.9), sarcopenia (80 vs 82%, P=0.8), fall (IRR : 1.38[0.76-2.51], P=0.3), infection (1.29 [0.85-1.97], P=0.2, cognition (P=0.5), depression (P=0.7), healthcare resource use (0.98 [0.59-1.61], P=0.9), death (P=0.91). OI increased from 4.3 [3.5-5.1] to 7.9 [6.9-8.9] (O3), 3.9 [3.2-4.7] to 6.8 [5.6-8.0] (CTRL) (Pinteraction = 0.004).
Conclusion: In a not severely impaired- NH population, our hypothesis of a slowdown of the independence decline was not verified compared with CTRL. Our results reinforce the national policy on nutritional prevention for community-dwelling older adults.
References: Trial registration: NCT05628155 (clinicaltrials.gov)
Disclosure of Interest: R. Thibault Grant / Research Support from: Valorex, Bleu Blanc Cœur, BPI France, E. Bajeux: None declared, G. Mairesse: None declared, Y. Gallien: None declared, B. Anato: None declared, K. Charras: None declared, V. Rioux: None declared, P. Legrand: None declared, M. Abbas: None declared, R. Le Bouquin-Jeannès: None declared, P. Weill: None declared, D. Somme: None declared