PP392 - COMPARISON OF PERMANENT AND TEMPORARY CENTRAL VENOUS CATHETERS IN PATIENTS RECEIVING PARENTERAL NUTRITION: A SAFETY ANALYSIS OF CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTIONS

PP392

COMPARISON OF PERMANENT AND TEMPORARY CENTRAL VENOUS CATHETERS IN PATIENTS RECEIVING PARENTERAL NUTRITION: A SAFETY ANALYSIS OF CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTIONS

B. Kelleci^1,*, M. Güngör², N. D. Gül³, N. Doğancı⁴, P. Onar⁴, F. Tamer⁴, S. Ataç⁴, N. Erten⁴, G. Telli Dizman³, G. Metan³, K. Demirkan¹, M. Halil²

¹Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, ²Department of Internal Medicine Division of Geriatrics, ³Department of Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine, ⁴Adult Clinical Nutrition Unit, Hacettepe University Hospitals, Ankara, Türkiye

Rationale: Central line-associated bloodstream infection (CLABSI) remains a significant complication in patients receiving parenteral nutrition (PN) via central venous catheters. This study aims to evaluate the safety of permanent (Port/Hickman) vs temporary central catheters.

Methods: Patients received PN via central lines in 2025 were retrospectively evaluated. CLABSI and nutrition specific CLABSI diagnosis was determined according to national surveillance guideline criteria established in 2026. Patients were divided into two groups: permanent and temporary central catheters.

Results: A total of 83 patients (with 38 permanent vs 45 temporary catheters) were included; The mean age of 58.7±17.5 years and 43 of them female. Most patients were followed in oncology (56.6%) units. CLABSI was detected in 16 patients (19.3%), with 12 (75%) developing infection during the PN period. CLABSIs per 1,000 catheter days were detected as 3.81vs6.63 (p=0.85), however, CLABSIs per 1,000 nutrition days were detected as 7.98 vs 7.33 in permanent and temporary catheter groups respectively (p=0.04). The PN days per 1,000 hospital days were 434.5 in the permanent and 213.3 in the temporary catheter group. The significant findings were higher incidence of hypophosphatemia (p=0.02) and longer catheter dwell time (median 36vs.23 days,p=0.003) in permanent catheter group, while higher rates of sepsis (p=0.04) in the temporary catheter group.

Conclusion: PN days proved more sensitive than catheter days for assessing CLABSI risk. The data indicated a higher incidence of infection within the permanent catheter group, despite it is generally being considered safer. PN itself remains a risk factor for CLABSI. Alongside infection risks from prolonged dwell times, permanent catheter use requires close monitoring for metabolic complications like hypophosphatemia.

Disclosure of Interest: None declared