PD768 - BEYOND STANDARD NUTRITIONAL ASSESSMENT: COMPUTED TOMOGRAPHY (CT)-DERIVED BODY COMPOSITION ANALYSIS DETECTS HIDDEN SARCOPENIA IN PATIENTS WITH PANCREATIC CANCER

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PD768

BEYOND STANDARD NUTRITIONAL ASSESSMENT: COMPUTED TOMOGRAPHY (CT)-DERIVED BODY COMPOSITION ANALYSIS DETECTS HIDDEN SARCOPENIA IN PATIENTS WITH PANCREATIC CANCER

K. Nikolakopoulou1,*, K. A. Poulia1, P. Sarantis2, D. Antoniadou3, A. Zampelas1,4, M. V. Karamouzis2

1Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 2Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 3Oncology Department of Daily Hospitality, Laikon General Hospital of Athens, Athens, Greece, 4Department of Human Sciences, School of Human Sciences, University of Nicosia, Nicosia, Cyprus

 

Rationale: Sarcopenia affects many patients with cancer and is associated with increased treatment toxicity and poor survival. The aim of this study was to compare standard nutritional assessment methods with computed tomography (CT)-derived body composition analysis in patients with pancreatic cancer (PC).

Methods: CT images at the third lumbar (L3) vertebral level from 26 patients [53.80% men, median age 72.00 (65.00-76.75) years] with PC were analyzed using SliceOmatic software to evaluate skeletal muscle index (SMI). Body weight was measured with calibrated scale and height with stadiometer to calculate body mass index (BMI) (weight/height2). Mid arm circumference (MAC) and triceps skinfolds (TSF) were measured via measuring tape and skinfold caliper, respectively, to derive mid arm muscle circumference (MAMC) [MAMC = MAC – (0.3142 × TSF)]. Handgrip strength (HGS) was assessed using a hand-held dynamometer.

Results: Median SMI, HGS, BMI and MAMC were 40.89 (36.15-46.76) cm2/m2, 12.00 (10.00-15.00) kg, 24.11 (21.59-26.11) kg/m2 and 27.18 (23.76-29.55) cm, respectively. According to CT-derived SMI, 96.20% of the patients demonstrated low muscle mass, using a cut-off of 52.40 cm2/m2 for males and 38.50 cm2/m2 for females. HGS detected low muscle strength in 90.50%, with a cut-off point of 27.00 kg for men and 16.00 kg for women. BMI and MAMC identified impaired nutritional status in 15.40% and 17.60%, respectively. McNemar analysis revealed significant differences between SMI and BMI (p<0.001), as well as SMI and MAMC (p<0.001).

Conclusion: CT-derived SMI, combined with HGS, was a superior marker compared to standard anthropometric measurements for detecting impaired nutritional status in patients with PC, as the latter underdiagnosed most sarcopenia cases.

Disclosure of Interest: None declared