LB060 - EFFECT OF SYMBIOTIC SUPPLEMENTATION ON NUTRITIONAL STATUS AND QUALITY OF LIFE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE ON HEMODIALYSIS

LB060

EFFECT OF SYMBIOTIC SUPPLEMENTATION ON NUTRITIONAL STATUS AND QUALITY OF LIFE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE ON HEMODIALYSIS

P. Miranda1,*, J. Ortiz -González 2, M. C. Jaquez -Gallardo2, A. Luna-Ortiz2, J. C. Herrera-Gutiérrez2, D. J. Contreras Domínguez2

1Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, 2Unidad de Terapia Renal , Zacatecas, Mexico

 

Rationale:  

Rationale: Protein-energy malnutrition (PEM) is prevalent among patients undergoing haemodialysis and is associated with dysfunction of the gut microbiota. The objective of this study was to evaluate the impact of symbiotic supplementation on nutritional status, biochemical parameters, gastrointestinal symptoms, and quality of life in individuals undergoing haemodialysis.(1,2)

 

 

Methods: Methods This study utilized a before-and-after design involving 36 participants from four hemodialysis centers in Zacatecas, Mexico. Each participant received a daily supplement containing 1x10^10 CFU of *Bifidobacterium longum*, 1x10^10 CFU of *Lactobacillus rhamnosus*, and 100 mg of agave fructans for a duration of four months. The nutritional status of the participants was assessed using the Malnutrition and Inflammation Score (MIS) at four different points in time: baseline, measurement 1, measurement 2, and the final assessment. Additionally, biochemical parameters, gastrointestinal symptoms (measured by the Gastrointestinal Symptom Rating Scale, GSRS), and quality of life (assessed by the KDQOL-SF36) were evaluated at baseline and again after four months. Statistical analyses including chi-square tests, Student's t-tests, and Friedman's test were employed to identify differences between groups, depending on the nature of the variables and the distribution of the data. A p-value of <0.05 was considered statistically significant.

 

 

Results: Results: Thirty-six patients (18 women and 18 men) were studied, with a mean age of 56.42 ± 14.35 years, a height of 1.61 ± 0.08 meters, a BMI of 25.39 ± 3.96, and a GFR of 6.30 ± 3.65.  There were significant changes observed  in several gastrointestinal symptoms. regurgitation (p=0.02), diarrhea (p=0.032), urgency (p=0.024) and loose stools (p=0.00) decreased significantly over the course of the study. Conversely, heartburn (p=0.00) and abdominal distention (p=0.003) increased significantly. Significant shifts in nutritional status were also noted. The proportion of patients with a normal nutritional status increased (p<0.042), while there were also significant changes (p<0.004) in mild malnutrition and severe malnutrition (p<0.00) see Table 1. There were no statistically significant differences in biochemical and clinical parameters, as well as quality of life.

 

Table 1. Nutritional status

 

MIS

Baseline 

Measurement 1 

Measurement 2 

Final Measurement 

Nutritional Status

 

 *

 **

 

 ***

Normal

41%

48%

49%

61%

Mild Malnutrition

19%

8%

7%

3%

Moderate Malnutrition

9%

8%

7%

17%

Severe Malnutrition

31%

36%

37%

19%

 

p<0.05 baseline vs measurement 1 * baseline vs measurement 2  ** measurement 1 vs final measurement ***

 

Conclusion: Conclusions Symbiotic supplementation may represent an effective intervention to enhance nutritional status and select GI symptoms in patients with advanced chronic kidney disease undergoing haemodialysis.

References: 1.--J Nephrol. 2023 Apr;36(3):873-883. doi: 10.1007/s40620-022-01560-1.

2.- J Cachexia Sarcopenia Muscle. 2011 Jun;2(2):119. doi: 10.1007/s13539-011-0026-6.

Disclosure of Interest: None declared