PP142 - THE EFFECT OF APPETITE IMPAIRMENT ON MALNUTRITION, FRAILTY, AND QUALITY OF LIFE IN PATIENTS WITH CHRONIC KIDNEY DISEASE
PP142
THE EFFECT OF APPETITE IMPAIRMENT ON MALNUTRITION, FRAILTY, AND QUALITY OF LIFE IN PATIENTS WITH CHRONIC KIDNEY DISEASE
M. Erken1, M. Kangalgil1,*, M. F. Aşkın2, O. Büyüktekeli2
1Department of Nutrition and Dietetics, 2Department of Nephrology, Sivas Cumhuriyet University, Sivas, Türkiye
Rationale: Chronic kidney disease (CKD) is associated with appetite impairment, malnutrition, and frailty, which adversely affect clinical outcomes and health-related quality of life (HRQoL), though their combined effects remain unclear. This study aimed to investigate the associations among appetite status, malnutrition, frailty, and HRQoL in patients with CKD.
Methods: This cross-sectional study included adult patients with CKD stage 3 or higher who were receiving care at a tertiary university hospital. Appetite was assessed using the Simplified Nutritional Appetite Questionnaire (SNAQ) and Visual Analog Scale (VAS). Malnutrition was diagnosed according to Global Leadership Initiative on Malnutrition (GLIM) criteria, and frailty was evaluated using the FRAIL scale. HRQoL was measured with the Kidney Disease Quality of Life Short Form (KDQOL-36). Multivariate linear regression analyses were performed to identify factors associated with HRQoL.
Results: The mean age of participants was 61.9 ± 15.5 years, 53.8% were female, and 89.2% had at least one comorbidity. The prevalence of impaired appetite was 55.4% (SNAQ) and 38.5% (VAS). Kidney disease–specific HRQoL domains, including burden and effects of disease, were significantly lower in patients with impaired appetite (p < 0.05). In multivariate analysis, frailty was independently associated with lower scores across all kidney disease–specific HRQoL domains (p ≤ 0.001), whereas impaired appetite was independently associated with worse effects of disease scores (p = 0.016).
Conclusion: Impaired appetite is common among patients with CKD and is associated with increased frailty and malnutrition, as well as adverse effects on kidney disease–specific quality of life domains. These findings underscore the clinical importance of routine assessment of appetite and frailty in CKD management to optimize patient-centered outcomes.
Disclosure of Interest: None declared