PT21 - BLOOD LEVELS OF TRYPTOPHAN, PHENYLALANINE AND TYROSINE INFLUENCE SLEEP.

PT21

BLOOD LEVELS OF TRYPTOPHAN, PHENYLALANINE AND TYROSINE INFLUENCE SLEEP.

P. Patriota^1,*, R. Luethold², R. Heinzer³, J. Ivanisevic⁴, P. Marques-Vidal^5,6

¹Evidence Nutri, Epalinges, ²Institute of Primary Health Care (BIHAM), Bern University, Bern, ³Centre d'investigation et de recherche sur le sommeil (CIRS), CHUV, ⁴Metabolomics group, ⁵Lausanne University- UNIL, ⁶Department of Internal Medicine, CHUV, Lausanne, Switzerland

Rationale: Sleep disorders affect people worldwide and have been associated with chronic diseases such as metabolic and mental health disorders. Whether sleep disorders are associated with changes in blood levels of specific amino acids such as Tryptophan or its metabolites is currently unknown. We assessed the association between Tryptophan, Tyrosine and Phenylalanine levels with sleep quality and characteristics.

Methods: Cross-sectional study using data from the CoLaus|HypnoLaus study, Lausanne, Switzerland. Blood levels of amino-acids were assessed by liquid chromatography-mass spectrometry. Sleep data included polysomnography (sleep efficiency, total sleep time, oxygen desaturation index – ODI, apnoea-hypopnea index – AHI, and wakefulness after sleep onset – WASO) and questionnaires: Pittsburgh Sleep Quality Index (PSQI) Epworth sleepiness scale (ESS), Ullanlinna Narcolepsy Scale (UNS), and STOP-BANG (risk of obstructive sleep apnoea).

Results: Data from 2,138 participants (57.2% females, mean age 54.1±8.7years) was analysed. Men had higher ESS and UNS, and higher levels of amino acids than women. In the multivariable-adjusted analysis adjusting for age, sex, body mass index and dietary intake, Tryptophan and Tyrosine were positively associated with BANG (standardized beta coefficients 0.131 and 0.183, respectively). Tyrosine was positively associated with total sleep time (0.179), ODI 3% (0.225), ODI 4% (0.216) and AHI (0.190). Phenylalanine was positively associated with sleep efficiency (0.199) and negatively with WASO (-0.182). No associations between amino acid levels and PSQI, UNS or ESS were found.

Conclusion: In a Swiss population-based study, blood Tryptophan and Tyrosine levels were associated with markers of obstructive sleep apnoea, while Phenylalanine levels were associated with better sleep efficiency.

Disclosure of Interest: None declared