P413 - MALNUTRITION-SARCOPENIA SYNDROME: A KEY DETERMINANT OF CLINICAL OUTCOMES IN ACUTE CARE SETTINGS

P413

MALNUTRITION-SARCOPENIA SYNDROME: A KEY DETERMINANT OF CLINICAL OUTCOMES IN ACUTE CARE SETTINGS

J. Lee^1,*, N.-H. Kim¹, J. H. Ohn¹, E. S. Kim¹, Y. Lim¹, H. W. Kim¹, H.-S. Park¹, J. Ryu¹, J. Kim¹, Y. Choi¹, J. E. Song¹, S.-W. Kim¹

¹Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic Of

Rationale: Malnutrition-sarcopenia syndrome (MSS) is a clinical condition characterized by the coexistence of both malnutrition and sarcopenia. The aim of this study is to investigate the relationship between MSS and clinical outcomes in an acute care setting.

Methods: This prospective observational study was conducted on patients admitted to the acute care ward at a tertiary-care medical center in South Korea between April 2022 and August 2023. Nutritional status was assessed using the Mini Nutritional Assessment (MNA), which classified patients into three groups: normally nourished, at risk of malnutrition, and malnourished. Sarcopenia was diagnosed by calculating the skeletal muscle index (SMI), derived from appendicular lean mass measured by bioelectrical impedance analysis divided by height squared (㎡).

Results: Among 1268 initially enrolled patients, 1189 who had both MNA and SMI measurements were included in this study, and 291 (18.4%) had MSS. Patients with MSS had a significantly longer length of hospital stay (LOS) than those without MSS (11.01 ± 8.82 days vs. 8.07 ± 7.19 days, p<0.001). Additionally, in-hospital mortality (IHM) was significantly higher in patients with MSS at 4.57% (10/219) compared to 1.86% (18/970) in patients without MSS (p=0.03). According to regression analysis results that included age, sex, Charlson Comorbidity Index (CCI), and MSS, LOS showed significant associations with MSS (β = 2.63, p<0.001) and CCI (β = 0.21, p=0.02). Furthermore, IHM was significantly associated with MSS (OR = 2.43, 95% CI: 1.09-5.46, p=0.03).

Conclusion: Our findings demonstrated that MSS at admission was associated with prolonged LOS and increased IHM. Therefore, the early identification of patients with MSS, combined with the provision of appropriate nutritional and rehabilitative interventions, could represent an effective strategy to improve clinical outcomes.

Disclosure of Interest: None declared