P709 - SYNERGISTIC EFFECTS OF CARDIOVASCULAR-KIDNEY-METABOLIC SYNDROME AND MALNUTRITION ON SARCOPENIA AND FRAILTY IN OLDER ADULTS

P709

SYNERGISTIC EFFECTS OF CARDIOVASCULAR-KIDNEY-METABOLIC SYNDROME AND MALNUTRITION ON SARCOPENIA AND FRAILTY IN OLDER ADULTS

N. T. Ozer^1,*, S. Akin², E. Akandere Barlas²

¹Department of Nutrition and Dietetics, Agri Ibrahim Cecen University, Agri, ²Department of Geriatrics, Erciyes University School of Medicine, Kayseri, Türkiye

Rationale: Cardiovascular-kidney-metabolic (CKM) syndrome has been defined recently as a constellation of metabolic disorders, chronic kidney disease, and cardiovascular diseases. Malnutrition (MN) is common among older adults and is associated with poor clinical outcomes, such as sarcopenia and frailty. The present study aimed to investigate the effects of the co-existence of CKM syndrome and MN on sarcopenia and frailty in older adults.

Methods: This cross-sectional study was conducted in the geriatric outpatient clinic. The CKM syndrome was defined as stages 0-4, incorporating the following: the assessment of obesity, metabolic risk factors, cardiovascular disease, and chronic kidney disease. The stage>3 was considered to be CKM syndrome. The assessment of MN was conducted using the MNA-SF. Sarcopenia was defined by EWGSOP-2 criteria. Frailty was defined by the Frail Score.

Results: The present study comprised 763 participants, with a median age of 70 years (IQR:65-75). Patients were divided into four groups (Figure 1). Following the adjustment of age, gender and BMI, multivariate logistic regression demonstrated that the presence of CKM syndrome alone (OR(95% CI):1.473(1.310-1.722), p<0.001), only MN (OR(95% CI):1.387(1.255-1.587), p=0.032), and both CKM syndrome and MN (OR (95% CI): 2.746(1.895-3.215), p<0.001) were significantly associated with sarcopenia. The multivariate logistic regression found that having CKM syndrome by itself (OR (95% CI): 1.184(1.109-1.311), p<0.001) and having both CKM syndrome and MN (OR(95%CI):2.150(1.929-3.434), p<0.001) were strongly linked to frailty.

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Conclusion: The study demonstrated that the presence of CKM syndrome alone was significantly associated with sarcopenia and frailty. The correlation between the presence of both CKM syndrome and MN, as well as sarcopenia and frailty, was significantly stronger than the correlation between CKM and MN alone.

Disclosure of Interest: None declared