P199 - THE INCIDENCE OF CHRONIC KIDNEY DISEASE BETWEEN NONALCOHOLIC FATTY LIVER AND WITHOUT NONALCOHOLIC FATTY LIVER PATIENTS WITH TYPE 2 DIABETES MELLITUS IN KYRGYZ POPULATION

P199

THE INCIDENCE OF CHRONIC KIDNEY DISEASE BETWEEN NONALCOHOLIC FATTY LIVER AND WITHOUT NONALCOHOLIC FATTY LIVER PATIENTS WITH TYPE 2 DIABETES MELLITUS IN KYRGYZ POPULATION

A. Z. Moldobaeva1,* on behalf of Muhammad Uzair, Saltanat Abazbekova S.

1Public health, International Higher School of medicine, Bishkek, Kyrgyzstan

 

Rationale: Nonalcoholic fatty liver disease (NAFLD), common in patients with T2DM, has been associated with a higher risk of chronic kidney disease (CKD), yet this relationship remains understudied in the local population

Methods: Study design: cross-sectional retrospective. The data was obtained between 2023 and 2025 from Vedanta University Hospital in Bishkek, Kyrgyzstan. Our study included 100 patients over 50 with T2DM. Glycated hemoglobin (HbA1C), lipid profile and creatinine were determined in the blood tests, and the body mass index (BMI) was calculated using anthropometric data. The estimated glomerular filtration rate (eGFR) level was utilized to quantify renal impairment. The eGFR was computed using the CKD-EPI. The Mann-Whitney U test was used to determine whether there was statistical difference between the two groups in these parameters. The Mindray DC 70 2021 model year of the equipment was used for liver ultrasounds as one of the instrumental research approaches. Patients are divided into 2 groups with non-alcoholic fatty liver disease and without non-alcoholic fatty liver disease.

Results: In our cohort, no statistically significant differences were observed in HbA1c levels, estimated glomerular filtration rate (eGFR), or lipid profiles between individuals with and without NAFLD. However, body mass index (BMI) differed significantly; patients with NAFLD had substantially higher BMI values (P < 0.005), indicating a strong association between obesity and hepatic steatosis

Conclusion: While our study did not establish a statistically significant association between NAFLD and CKD in patients with T2DM, the findings highlight the importance of obesity as a contributing factor to NAFLD in this population. 

Disclosure of Interest: A. Moldobaeva Grant / Research Support from: no conflict, Consultant for: no conflict, Other: no conflict