PT14 - BEYOND MUSCLE AND FAT: THE SYNERGISTIC RISK OF SARCOPENIC OBESITY FOR COGNITIVE FRAILTY IN OLDER ADULTS WITH DIABETES
PT14
"BEYOND MUSCLE AND FAT: THE SYNERGISTIC RISK OF SARCOPENIC OBESITY FOR COGNITIVE FRAILTY IN OLDER ADULTS WITH DIABETES"
H. K. Yıldırım1, M. Hafizoğlu2, A. Okyar Baş2, M. Eşme2, B. B. Doğu2, M. G. Halil2, M. Cankurtaran2, C. Balcı2,*
1Hacettepe University Faculty of Medicine Department of Internal Medicine, 2Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine, Ankara, Türkiye
Rationale: This study aimed to apply ESPEN/EASO SO criteria to identify SO in community-dwelling older adults with diabetes (OAD) and evaluate its association with cognitive frailty (CF). We also examined whether the combined entity of SO offers additional predictive value for CF beyond its components.
Methods: This cross-sectional study included outpatient OAD. Participants were classified into four groups The non-sarcopenic, non-obese (NS-NO) group included individuals with normal muscle strength, normal muscle mass, and normal fat mass. The altered muscle function only (AMF) group consisted of those with reduced muscle strength, along with either reduced muscle mass and normal or increased fat mass, or normal muscle mass and increased fat mass. The altered body composition only (ABC) group comprised individuals with normal muscle strength but reduced muscle mass, accompanied by either normal or increased fat mass. Finally, the sarcopenic obesity (SO) group included participants with reduced muscle strength, reduced muscle mass, and increased fat mass. CF was defined as the coexistence of physical frailty and mild cognitive impairment.
Results: Among 301 participants (mean age: 72.3 ± 5.7 years; 62.8% women), 53 (17.6%) had SO, 26 (8.6%) had ABC, 119 (39.6%) had AMF, and 103 (34.2%) were NS-NO. Using the NS-NO group as the reference category in multivariable regression analyses adjusted for potential confounders, only the SO group showed a significant association with cognitive frailty (OR: 3.05, 95% CI: 1.28–7.27, p = 0.04). In contrast, neither the AMF group (OR: 0.91, 95% CI: 0.25–3.18, p = 0.87) nor the ABC group (OR: 0.32, 95% CI: 0.03–2.85, p = 0.31) was significantly associated with cognitive frailty.
Conclusion: These findings highlight SO as a distinct, synergistic risk factor for CF, emphasizing the need for targeted interventions in older adults with diabetes.
Disclosure of Interest: None declared