PP094 - MYOINFLAMMATORY PHENOTYPE IN DISEASE-RELATED MALNUTRITION AND 6-MONTH SURVIVAL: RESULTS FROM THE DRECO STUDY

PP094

MYOINFLAMMATORY PHENOTYPE IN DISEASE-RELATED MALNUTRITION AND 6-MONTH SURVIVAL: RESULTS FROM THE DRECO STUDY

M. García Olivares¹, J. J. López Gómez², Y. García Delgado³, P. Guirado Peláez ¹, A. Zabalegui Eguinoa⁴, C. Porca Fernández ⁵, M. Á. Valero Zanuy⁶, C. M. Alzas Teomiro⁷, I. Bretón Lesmes⁸, J. M. Guardia Baena⁹, D. Bellido Guerrero⁵, D. D. L. Roman¹⁰, G. Olveira¹¹, J. M. Garcia Almeida^1,* on behalf of DRECO

¹Endocrinology and Nutrition, VIRGEN DE LA VICTORIA HOSPITAL, MALAGA, ²Endocrinology and Nutrition, HOSPITAL CLINICO UNIVERSITARIO, VALLADOLID, ³Endocrinology and Nutrition, COMPLEJO HOSPITALARIO UNIVERSITARIO INSULAR-MATERNO INFANTIL , CANARIAS, ⁴Endocrinology and Nutrition, HOSPITAL VALL D´HEBRÓN, BARCELONA, ⁵Endocrinology and Nutrition, COMPLEJO HOSPITALARIO UNIVERSITARIO DE FERROL, GALICIA, ⁶Endocrinology and Nutrition, COMPLEJO HOSPITALARIO UNIVERSITARIO 12 DE OCTUBRE, MADRID, ⁷Endocrinology and Nutrition, HOSPITAL COMPLEJO HOSPITALARIO REINA SOFÍA, CORDOBA, ⁸Endocrinology and Nutrition, HOSPITAL GREGORIO MARAÑON , MADRID, ⁹Endocrinology and Nutrition, HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES , GRANADA, ¹⁰Endocrinology and Nutrition, Hospital Clínico Universitario de Valladolid., VALLADOLID, ¹¹Endocrinology and Nutrition, REGIONAL UNIVERSITARIO HOSPITAL, MALAGA, Spain

Rationale: Disease-related malnutrition (DRM), particularly when associated with inflammation and morphofunctional impairment, may negatively impact hospital survival. Identifying high-risk clinical phenotypes could improve prognostic stratification and guide targeted interventions.

Methods: A total of 695 hospitalized patients from the multicenter DRECO study were analyzed. A myoinflammatory phenotype was defined by the coexistence of inflammatory markers (CRP >5 mg/dL or bioimpedance parameters [BIA Akern® Nutrilab]: phase angle <1.65 and Na/K ratio >1.2) and muscle dysfunction (dynapenia: women <16 kg; men <27 kg). Kaplan–Meier survival curves at 3 and 6 months were estimated. Univariable and multivariable Cox regression models adjusted for age and sex were performed.

Results: The myoinflammatory phenotype with functional impairment was associated with reduced survival from early follow-up: 3 months: 85.6% vs 96.0%; 6 months: 73.7% vs 92.5%. In multivariable analysis, this phenotype was an independent predictor of mortality (HR: 3.26; 95% CI: 2.11–5.05; p < 0.001), after adjustment for age (HR: 1.02; p = 0.011). Sex was not significant.

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Conclusion: The myoinflammatory phenotype with functional impairment is independently associated with lower 6-month survival in hospitalized patients with DRM or nutritional risk. Early identification may help prioritize targeted nutritional and functional interventions to improve prognosis.

Disclosure of Interest: None declared