PD518 - INTAKE OF SALICYLATES AND THEIR CONCENTRATION IN URINE IN PREGNANT WOMEN WITH PREECLAMPSIA

PD518

INTAKE OF SALICYLATES AND THEIR CONCENTRATION IN URINE IN PREGNANT WOMEN WITH PREECLAMPSIA

J. Suliburska^1,*, M. Czuba², M. Karaźniewicz-Łada³, Z. Gaj², M. Grzesiak²

¹Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poznan, ²Polish Mother’s Health Centre Institute in Łódź, Łódź, ³Department of Physical Pharmacy and Pharmacokinetics, Poznań University of Medical Sciences, Poznan, Poland

Rationale: Salicylates are naturally present in plants. In medicine, acetylsalicylic acid (aspirin) is widely used as a preventive medicine for preeclampsia in pregnancy.Therefore, this study aimed to determine total salicylate intake and urinary salicylate concentration in pregnant women with preeclampsia.

Methods: This study was conducted on 41 pregnant women with preeclampsia (PE) and 45 healthy pregnant women (C) aged 23–44 years. The study was conducted in the third trimester of pregnancy, prior to delivery. The PE group was at 30–42 weeks of gestation, and the C group was at 38-41 weeks of gestation. We used a validated questionnaire and a 24 h recall nutrition interview. The results were analyzed using the original database on salicylate content in food and the computer software package Aliant.First morning urine was collected, and total salicylates were measured using the UHPLC-MS/MS method. Women taking salicylate-containing medications were excluded from the study. A statistical analysis of the results was performed using Statistica 13.3. The results are shown as median and 1st and 3rd quartiles.

Results: It was found that the total intake of salicylates (PE: 445.45, 254.07-680.92 vs C: 353.81, 253.90-570.56 µg/day) and their urinary concentrations (PE: 0.87, 0.53-2.09 vs C:1.00, 0.65-2.03 mg/L) were comparable between groups. The main food sources of salicylates in women were as follows: buckwheat and basil, in group PE, additionally, cauliflower, and in group C, pickled cucumbers and berries.

The mean pre-pregnancy BMI did not differ between groups, but the newborn weight was significantly lower in the PE group (3020, 2555-3525 g) than in the C group (3630, 3460-3800 g).

Conclusion: In conclusion, no association is suggested between dietary salicylate intake and the development of preeclampsia in pregnant women.

This study was funded by NCN (grant no 2021/43/B/NZ9/00177).

Disclosure of Interest: None declared