PP255 - ASSOCIATION BETWEEN HOME PARENTERAL NUTRITION AND BODY COMPOSITION IN PATIENTS WITH CHRONIC INTESTINAL FAILURE

PP255

ASSOCIATION BETWEEN HOME PARENTERAL NUTRITION AND BODY COMPOSITION IN PATIENTS WITH CHRONIC INTESTINAL FAILURE

F. E. C. van de Ven¹, H. E. E. Zweers- van Essen¹, H. JAGER-WITTENAAR^1,2,3,*, G. J. A. Wanten¹, M. J. M. D. van Asseldonk¹

¹Department of Gastroenterology and Hepatology - Dietetics, Radboud university medical center, Nijmegen, ²Research Group Healthy Ageing, Allied Health Care and Nursing, Hanze University of Allied Sciences Groningen, Groningen, Netherlands, ³Department of Physiology and Anatomy, Faculty of Physcial Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium

Rationale: Chronic intestinal failure (CIF) is a serious condition characterised by insufficient intestinal absorption, with home parenteral nutrition (HPN) as a primary treatment. Previous research in this setting reported a suboptimal body composition with low fat-free mass (FFM) and high fat percentage in patients with CIF, despite their healthy body mass index. Therefore, the aim of this study was to investigate associations between HPN prescriptions and body composition outcomes.

Methods: A retrospective cohort study was conducted including 126 CIF patients on HPN treated at the Radboud university medical center. Body composition outcomes were evaluated using multi-frequency bioelectrical impedance analysis (MF-BIA), while HPN prescription data were extracted from electronic patient records. A linear mixed model was used to analyse associations between HPN prescription and MF-BIA outcomes, adjusted for age and sex. 

Results: Protein and lipid intake via HPN were positively associated with FFM (β=0.01, β=0.003), FFM index (FFMI) (β=0.007, β=0.001), appendicular skeletal muscle mass (ASMM) (β=0.015, β= -0.004), ASMM index (β=0.01, β=0.002), while protein intake was negatively associated with fat percentage (β= -0.01). HPN frequency (days/week) was negatively associated with FFM and FFMI (β= -0.03, β= -0.03), whereas the percentage of energy requirement met via HPN was negatively associated with all body composition parameters except fat percentage.

Conclusion: Various body composition parameters and HPN prescriptions were significantly entwined in this population. Our results suggest that increasing protein intake via HPN may improve body composition in CIF patients, particularly in those with low FFM. Further research should explore the extent of this positive association, taking into account residual oral intake and physical activity. 

Disclosure of Interest: None declared