PD043 - DECODING THE MALNUTRITION–INFLAMMATION–FUNCTIONAL DECLINE TRIAD IN CHRONIC KIDNEY DISEASE: A GLIM-GUIDED CLINICAL STUDY

PD043

DECODING THE MALNUTRITION–INFLAMMATION–FUNCTIONAL DECLINE TRIAD IN CHRONIC KIDNEY DISEASE: A GLIM-GUIDED CLINICAL STUDY

B. Bhattacharjee^1,1,2,*, S. Sarkar¹, J. Khaitan¹, A. M. Raza¹, B. Siddiquie¹, I. Chakravarti³, D. Dutta³, A. Dutta¹

¹Dietetics and Applied Nutrition, Amity University Kolkata, ²Dietetics, Clinical Nutrition and Wellness Solutions, ³Dietetics, CK Birla Hospitals CMRI Kolkata, Kolkata, India

 

Rationale: Chronic kidney disease is frequently associated with underdiagnosed malnutrition due to the limitations of conventional markers such as BMI. Integrating GLIM Criteria with functional measures like handgrip strength and inflammatory markers provides a comprehensive approach for early detection, risk stratification, and improved clinical management of CKD patients.

Methods: Cross-sectional hospital-based study conducted among CKD patients

Sample size: 112 adults selected via convenience sampling

Ethical approval obtained and written informed consent taken

Data collected: demographic, clinical, dietary, and biochemical parameters

Nutritional status assessed using GLIM Criteria

Handgrip strength measured using a digital dynamometer

Anthropometric measurements: height, weight, BMI

Biochemical parameters: hemoglobin, albumin, creatinine, CRP

Statistical analysis performed using SPSS (chi-square, correlation, regression)

Results: Malnutrition increased with CKD stage and dialysis. GLIM Criteria enabled accurate detection beyond BMI, while albumin declined with severity. CKD stage and age were key risk factors.

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Conclusion: GLIM-based assessment reveals a high burden of malnutrition in CKD patients, strongly linked to inflammation and reduced handgrip strength. Functional decline is the strongest predictor, with females showing greater severity, emphasizing the need for integrated nutritional screening.

References: • Rashid I, Bashir A, Tiwari P et al. (2021). Global estimates of malnutrition in CKD vs India: A systematic review & meta-analysis. Clin Epidemiol Glob Health, 12.

• Huang H et al. (2024). Validity of GLIM criteria in non-dialysis CKD patients. Front Nutr, 11:1340153. https://doi.org/10.3389/fnut.2024.1340153

• Silva MZC, Cederholm T, Gonzalez MC et al. (2023). GLIM criteria in CKD: applicability & challenges. Clin Nutr, 42(6):937–943. https://doi.org/10.1016/j.clnu.2023.04.019

Disclosure of Interest: None declared