PD204 - SURVEY OF HYPOSELENEMIA IN AN ACUTE CARE HOSPITAL

PD204

SURVEY OF HYPOSELENEMIA IN AN ACUTE CARE HOSPITAL

A. Naganuma^1,*, S. Oikawa², T. Sekiguchi², N. Yamai³, K. Ichikawa⁴, M. Inazuka⁴, K. Ito⁴, T. Ito⁴, S. Hoshino⁴, H. Aoki⁴, N. Itagaki⁵, Y. Miyamae⁶, H. Ogihara⁷, M. Inagawa⁸, T. Tanaka⁹, T. Ogawa⁶

¹Department of Gastroenterology, ²Department of Pharmacy, ³Department of Clinical Laboratory, ⁴Department of Nutrition Management, ⁵Department of Nursing, ⁶Department of Surgery, ⁷Department of Rehabilitation, ⁸Department of Dental and Oral Surgery, ⁹Department of Palliative Care, NHO Takasaki General Medical Center, Takasaki, Japan

Rationale: Selenium deficiency causes cardiomyopathy, impaired immune function, and skeletal muscle disorders, yet clinical awareness remains insufficient. An injectable selenium preparation received regulatory approval in Japan in June 2019. This study investigated the clinical management of hyposelenemia in an acute care hospital.

Methods: Ninety-eight patients who underwent serum selenium measurement between July 2019 and December 2025 were enrolled. Patient demographics, measurement frequency by clinical department, the distribution of serum selenium concentrations, and supplementation rates in patients with hyposelenemia were analysed retrospectively. Factors contributing to hyposelenemia were explored using multivariate logistic regression.

Results: Patient demographics: 58 males, median age 72 years, median BMI 21.1 kg/m², median serum albumin 3.2 g/dL, and median serum prealbumin 15.2 mg/dL. The median serum selenium concentration was 99 µg/L. Serum selenium was measured during hospitalisation in 51 patients. Primary underlying conditions were liver cirrhosis (n=40), malignant neoplasm (n=27), chronic liver disease (n=9), malnutrition (n=5), and gastrointestinal disease (n=5). The gastroenterology department accounted for the greatest number of patients (n=73). Hyposelenemia, defined as serum selenium <107 µg/L, was identified in 63 patients. Only 2 patients received selenium supplementation. Logistic regression identified two independent factors: measurement during hospitalisation (OR 3.66, 95% CI 1.17–11.46, p=0.026) and low serum prealbumin (OR 5.21, 95% CI 1.24–21.86, p = 0.024).

Conclusion: Hyposelenemia was identified in two-thirds of patients tested; however, the supplementation rate was remarkably low. Patients with low serum prealbumin may have concurrent hyposelenemia, warranting greater clinical vigilance and proactive supplementation in this population.

Disclosure of Interest: None declared